Bigels as drug delivery systems: From their components to their applications

Bigels are systems that usually result from mixing a hydrogel and an organogel: the aqueous phase is commonly formed by a hydrophilic biopolymer, whereas the organic phase comprises a gelled vegetable oil because of the presence of an organogelator. The proportion of the corresponding gelling agent...

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Authors: Martín Illana, Araceli, Notario Pérez, Fernando, Cazorla Luna, Raúl, Ruiz Caro, Roberto, Bonferoni, Maria C., Tamayo, Aitana, Veiga Ochoa, María Dolores
Format: article
Publication Date:2021
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/4713
Online Access:https://hdl.handle.net/20.500.14352/4713
Access Level:Open access
Keyword:615.4
Hydrogel
Organogel
Organogelator
Bigel manufacturing
Bigel characterization
Drug delivery bigels
Tecnología farmaceútica
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oai_identifier_str oai:docta.ucm.es:20.500.14352/4713
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spelling Bigels as drug delivery systems: From their components to their applicationsMartín Illana, AraceliNotario Pérez, FernandoCazorla Luna, RaúlRuiz Caro, RobertoBonferoni, Maria C.Tamayo, AitanaVeiga Ochoa, María Dolores615.4HydrogelOrganogelOrganogelatorBigel manufacturingBigel characterizationDrug delivery bigelsTecnología farmaceúticaBigels are systems that usually result from mixing a hydrogel and an organogel: the aqueous phase is commonly formed by a hydrophilic biopolymer, whereas the organic phase comprises a gelled vegetable oil because of the presence of an organogelator. The proportion of the corresponding gelling agent in each phase, the organogel/hydrogel ratio, and the mixing temperature and speed all need to be taken into consideration for bigel manufacturing. Bigels, which are particularly useful drug delivery systems, have already been formulated for transdermal, buccal, and vaginal routes. Mechanical assessments and microscopy are the most reported characterization techniques. As we review here, their composition and unique structure confer promising drug delivery attributes, such as mucoadhesion, the ability to control drug release, and the possibility of including both hydrophilic and lipophilic drugs in the same system.ElsevierUniversidad Complutense de Madrid20212021-12-2020212021-12-20journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/4713reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/47132026-06-02T12:44:21Z
dc.title.none.fl_str_mv Bigels as drug delivery systems: From their components to their applications
title Bigels as drug delivery systems: From their components to their applications
spellingShingle Bigels as drug delivery systems: From their components to their applications
Martín Illana, Araceli
615.4
Hydrogel
Organogel
Organogelator
Bigel manufacturing
Bigel characterization
Drug delivery bigels
Tecnología farmaceútica
title_short Bigels as drug delivery systems: From their components to their applications
title_full Bigels as drug delivery systems: From their components to their applications
title_fullStr Bigels as drug delivery systems: From their components to their applications
title_full_unstemmed Bigels as drug delivery systems: From their components to their applications
title_sort Bigels as drug delivery systems: From their components to their applications
dc.creator.none.fl_str_mv Martín Illana, Araceli
Notario Pérez, Fernando
Cazorla Luna, Raúl
Ruiz Caro, Roberto
Bonferoni, Maria C.
Tamayo, Aitana
Veiga Ochoa, María Dolores
author Martín Illana, Araceli
author_facet Martín Illana, Araceli
Notario Pérez, Fernando
Cazorla Luna, Raúl
Ruiz Caro, Roberto
Bonferoni, Maria C.
Tamayo, Aitana
Veiga Ochoa, María Dolores
author_role author
author2 Notario Pérez, Fernando
Cazorla Luna, Raúl
Ruiz Caro, Roberto
Bonferoni, Maria C.
Tamayo, Aitana
Veiga Ochoa, María Dolores
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.4
Hydrogel
Organogel
Organogelator
Bigel manufacturing
Bigel characterization
Drug delivery bigels
Tecnología farmaceútica
topic 615.4
Hydrogel
Organogel
Organogelator
Bigel manufacturing
Bigel characterization
Drug delivery bigels
Tecnología farmaceútica
description Bigels are systems that usually result from mixing a hydrogel and an organogel: the aqueous phase is commonly formed by a hydrophilic biopolymer, whereas the organic phase comprises a gelled vegetable oil because of the presence of an organogelator. The proportion of the corresponding gelling agent in each phase, the organogel/hydrogel ratio, and the mixing temperature and speed all need to be taken into consideration for bigel manufacturing. Bigels, which are particularly useful drug delivery systems, have already been formulated for transdermal, buccal, and vaginal routes. Mechanical assessments and microscopy are the most reported characterization techniques. As we review here, their composition and unique structure confer promising drug delivery attributes, such as mucoadhesion, the ability to control drug release, and the possibility of including both hydrophilic and lipophilic drugs in the same system.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-20
2021
2021-12-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/4713
url https://hdl.handle.net/20.500.14352/4713
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419461041192960
score 15,300724

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