Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle

A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the fo...

Descripción completa

Detalles Bibliográficos
Autores: Gómez González, Belén, Barroso Ceballos, Sonia Inés, Herrera Moyano, Emilia, Aguilera López, Andrés
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/98268
Acceso en línea:https://hdl.handle.net/11441/98268
https://doi.org/10.1080/15384101.2020.1728015
Access Level:acceso abierto
Palabra clave:DNA damage response
DNA-RNA hybrids
Genetic instability
Postreplication repair
Replicative stress
id ES_c94a2e9803ec8d4ee7eb3b7f684e9c4a
oai_identifier_str oai:idus.us.es:11441/98268
network_acronym_str ES
network_name_str España
repository_id_str
spelling Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycleGómez González, BelénBarroso Ceballos, Sonia InésHerrera Moyano, EmiliaAguilera López, AndrésDNA damage responseDNA-RNA hybridsGenetic instabilityPostreplication repairReplicative stressA large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the formation of DNA-RNA hybrids, as we have recently found through an siRNA screening. Three major DDR pathways were defined to participate in the protection against DNA-RNA hybrids: ATM/CHK2, ATR/CHK1 and Postreplication Repair (PRR). Based on these observations, we envision different scenarios of DNA-RNA hybridization and their consequent DNA damage.European Research Council ERC2014 AdG669898 TARLOOPTaylor & FrancisGenética2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/98268https://doi.org/10.1080/15384101.2020.1728015reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésCell Cycle, 19 (5), 525-531.ERC2014 AdG669898 TARLOOPhttps://doi.org/10.1080/15384101.2020.1728015info:eu-repo/semantics/openAccessoai:idus.us.es:11441/982682026-06-17T12:51:07Z
dc.title.none.fl_str_mv Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
title Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
spellingShingle Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
Gómez González, Belén
DNA damage response
DNA-RNA hybrids
Genetic instability
Postreplication repair
Replicative stress
title_short Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
title_full Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
title_fullStr Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
title_full_unstemmed Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
title_sort Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
dc.creator.none.fl_str_mv Gómez González, Belén
Barroso Ceballos, Sonia Inés
Herrera Moyano, Emilia
Aguilera López, Andrés
author Gómez González, Belén
author_facet Gómez González, Belén
Barroso Ceballos, Sonia Inés
Herrera Moyano, Emilia
Aguilera López, Andrés
author_role author
author2 Barroso Ceballos, Sonia Inés
Herrera Moyano, Emilia
Aguilera López, Andrés
author2_role author
author
author
dc.contributor.none.fl_str_mv Genética
dc.subject.none.fl_str_mv DNA damage response
DNA-RNA hybrids
Genetic instability
Postreplication repair
Replicative stress
topic DNA damage response
DNA-RNA hybrids
Genetic instability
Postreplication repair
Replicative stress
description A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the formation of DNA-RNA hybrids, as we have recently found through an siRNA screening. Three major DDR pathways were defined to participate in the protection against DNA-RNA hybrids: ATM/CHK2, ATR/CHK1 and Postreplication Repair (PRR). Based on these observations, we envision different scenarios of DNA-RNA hybridization and their consequent DNA damage.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/98268
https://doi.org/10.1080/15384101.2020.1728015
url https://hdl.handle.net/11441/98268
https://doi.org/10.1080/15384101.2020.1728015
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cell Cycle, 19 (5), 525-531.
ERC2014 AdG669898 TARLOOP
https://doi.org/10.1080/15384101.2020.1728015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419358332125184
score 15,300719

Similares en LA Referencia