Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia

Gray matter networks are altered with amyloid accumulation in the earliest stage of AD, and are associated with decline throughout the AD spectrum. It remains unclear to what extent gray matter network abnormalities are associated with hyperphosphorylated-tau (p-tau). We studied the relationship of...

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Autores: Lorenzini, Luigi, Ingala, Silvia, Wottschel, Viktor, Wink, Alle Meije, Mutsaerts, Henk, Haller, Sven, Blennow, Kaj, O'Brien, John T., Frisoni, Giovanni B., Chételat, Gael, Payoux, Pierre, Martínez Lage, Pablo, Waldman, Adam, Wardlaw, Joanna, Ritchie, Craig, Gispert, Juan Domingo, Visser, Pieter Jelle, Scheltens, Philip, Barkhof, Frederik, Tijms, Betty M.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/60235
Acesso em linha:http://hdl.handle.net/10230/60235
http://dx.doi.org/10.1016/j.nbas.2022.100054
Access Level:Acceso aberto
Palavra-chave:Amyloid
Brain connectivity
Gray matter networks
Preclinical Alzheimer
Tau
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spelling Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementiaLorenzini, LuigiIngala, SilviaWottschel, ViktorWink, Alle MeijeMutsaerts, HenkHaller, SvenBlennow, KajO'Brien, John T.Frisoni, Giovanni B.Chételat, GaelPayoux, PierreMartínez Lage, PabloWaldman, AdamWardlaw, JoannaRitchie, CraigGispert, Juan DomingoVisser, Pieter JelleScheltens, PhilipBarkhof, FrederikTijms, Betty M.AmyloidBrain connectivityGray matter networksPreclinical AlzheimerTauGray matter networks are altered with amyloid accumulation in the earliest stage of AD, and are associated with decline throughout the AD spectrum. It remains unclear to what extent gray matter network abnormalities are associated with hyperphosphorylated-tau (p-tau). We studied the relationship of cerebrospinal fluid (CSF) p-tau181 with gray matter networks in non-demented participants from the European Prevention of Alzheimer's Dementia (EPAD) cohort, and studied dependencies on amyloid and cognitive status. Gray matter networks were extracted from baseline structural 3D T1w MRI. P-tau181 and abeta were measured with the Roche cobas Elecsys System. We studied the associations of CSF biomarkers levels with several network's graph properties. We further studied whether the relationships of p-tau 181 and network measures were dependent on amyloid status and cognitive stage (CDR). We repeated these analyses for network properties at a regional level, where we averaged local network values across cubes within each of 116 areas as defined by the automated anatomical labeling (AAL) atlas. Amyloid positivity was associated with higher network size and betweenness centrality, and lower gamma, clustering and small-world coefficients. Higher CSF p-tau 181 levels were related to lower betweenness centrality, path length and lambda coefficients (all p < 0.01). Three-way interactions between p-tau181, amyloid status and CDR were found for path length, lambda and clustering (all p < 0.05): Cognitively unimpaired amyloid-negative participants showed lower path length and lambda values with higher CSF p-tau181 levels. Amyloid-positive participants with impaired cognition demonstrated lower clustering coefficients in association to higher CSF p-tau181 levels. Our results suggest that alterations in gray matter network clustering coefficient is an early and specific event in AD.Elsevier202420242022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60235http://dx.doi.org/10.1016/j.nbas.2022.100054reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAging Brain. 2022 Oct 23;2:100054© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/602352026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
title Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
spellingShingle Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
Lorenzini, Luigi
Amyloid
Brain connectivity
Gray matter networks
Preclinical Alzheimer
Tau
title_short Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
title_full Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
title_fullStr Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
title_full_unstemmed Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
title_sort Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia
dc.creator.none.fl_str_mv Lorenzini, Luigi
Ingala, Silvia
Wottschel, Viktor
Wink, Alle Meije
Mutsaerts, Henk
Haller, Sven
Blennow, Kaj
O'Brien, John T.
Frisoni, Giovanni B.
Chételat, Gael
Payoux, Pierre
Martínez Lage, Pablo
Waldman, Adam
Wardlaw, Joanna
Ritchie, Craig
Gispert, Juan Domingo
Visser, Pieter Jelle
Scheltens, Philip
Barkhof, Frederik
Tijms, Betty M.
author Lorenzini, Luigi
author_facet Lorenzini, Luigi
Ingala, Silvia
Wottschel, Viktor
Wink, Alle Meije
Mutsaerts, Henk
Haller, Sven
Blennow, Kaj
O'Brien, John T.
Frisoni, Giovanni B.
Chételat, Gael
Payoux, Pierre
Martínez Lage, Pablo
Waldman, Adam
Wardlaw, Joanna
Ritchie, Craig
Gispert, Juan Domingo
Visser, Pieter Jelle
Scheltens, Philip
Barkhof, Frederik
Tijms, Betty M.
author_role author
author2 Ingala, Silvia
Wottschel, Viktor
Wink, Alle Meije
Mutsaerts, Henk
Haller, Sven
Blennow, Kaj
O'Brien, John T.
Frisoni, Giovanni B.
Chételat, Gael
Payoux, Pierre
Martínez Lage, Pablo
Waldman, Adam
Wardlaw, Joanna
Ritchie, Craig
Gispert, Juan Domingo
Visser, Pieter Jelle
Scheltens, Philip
Barkhof, Frederik
Tijms, Betty M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Amyloid
Brain connectivity
Gray matter networks
Preclinical Alzheimer
Tau
topic Amyloid
Brain connectivity
Gray matter networks
Preclinical Alzheimer
Tau
description Gray matter networks are altered with amyloid accumulation in the earliest stage of AD, and are associated with decline throughout the AD spectrum. It remains unclear to what extent gray matter network abnormalities are associated with hyperphosphorylated-tau (p-tau). We studied the relationship of cerebrospinal fluid (CSF) p-tau181 with gray matter networks in non-demented participants from the European Prevention of Alzheimer's Dementia (EPAD) cohort, and studied dependencies on amyloid and cognitive status. Gray matter networks were extracted from baseline structural 3D T1w MRI. P-tau181 and abeta were measured with the Roche cobas Elecsys System. We studied the associations of CSF biomarkers levels with several network's graph properties. We further studied whether the relationships of p-tau 181 and network measures were dependent on amyloid status and cognitive stage (CDR). We repeated these analyses for network properties at a regional level, where we averaged local network values across cubes within each of 116 areas as defined by the automated anatomical labeling (AAL) atlas. Amyloid positivity was associated with higher network size and betweenness centrality, and lower gamma, clustering and small-world coefficients. Higher CSF p-tau 181 levels were related to lower betweenness centrality, path length and lambda coefficients (all p < 0.01). Three-way interactions between p-tau181, amyloid status and CDR were found for path length, lambda and clustering (all p < 0.05): Cognitively unimpaired amyloid-negative participants showed lower path length and lambda values with higher CSF p-tau181 levels. Amyloid-positive participants with impaired cognition demonstrated lower clustering coefficients in association to higher CSF p-tau181 levels. Our results suggest that alterations in gray matter network clustering coefficient is an early and specific event in AD.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60235
http://dx.doi.org/10.1016/j.nbas.2022.100054
url http://hdl.handle.net/10230/60235
http://dx.doi.org/10.1016/j.nbas.2022.100054
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Aging Brain. 2022 Oct 23;2:100054
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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