Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
Amyloid-beta (A beta) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to A beta and tau pathogenes...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p4733 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4733 https://ddd.uab.cat/record/243795 |
| Access Level: | acceso abierto |
| Palabra clave: | aging Alzheimer&apos s disease amyloid PET cognition connectivity analysis Tau PET |
| Sumario: | Amyloid-beta (A beta) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to A beta and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory-based positron emission tomography (PET) analytical approaches, within and between tau and A beta PET modalities, and tested the effects on cognitive changes in cognitively normal older adults (CN). Particularly, we focused on the network interdigitations of A beta and tau deposits, along with cognitive test scores in CN at both baseline and 2-year follow-up (FU). We found highly significant A beta-tau network integrations in AD vulnerable areas, as well as significant associations between those A beta-tau interdigitations and general cognitive impairment in CN at baseline and FU. Our findings suggest a distinctive contribution of interlinking network relationships between A beta and tau deposits in heteromodal areas of the human brain. They support a network-based interaction between A beta and tau accumulations as a key factor for cognitive deterioration in CN prior to dementia. |
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