Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?

Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and R...

Descripción completa

Detalles Bibliográficos
Autores: Sanmartí, Raimon, Frade-Sosa, Beatriz, Morlà, Rosa, Castellanos-Moreira, Raul, Cabrero-Villalba, Sonia, Ramirez, Julio, Salvador, Georgina, Haro Villar, Isabel, Cañete, Juan D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/235791
Acceso en línea:http://hdl.handle.net/10261/235791
Access Level:acceso abierto
Palabra clave:Palindromic rheumatism
Rheumatoid arthritis
ACPA
pre-RA
id ES_c8d026f1913dceecbf7596e47ff299f4
oai_identifier_str oai:digital.csic.es:10261/235791
network_acronym_str ES
network_name_str España
repository_id_str
spelling Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?Sanmartí, RaimonFrade-Sosa, BeatrizMorlà, RosaCastellanos-Moreira, RaulCabrero-Villalba, SoniaRamirez, JulioSalvador, GeorginaHaro Villar, IsabelCañete, Juan D.Palindromic rheumatismRheumatoid arthritisACPApre-RAPalindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis.Peer reviewedFrontiers MediaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/235791reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3389/fmed.2021.657983Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2357912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
title Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
spellingShingle Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
Sanmartí, Raimon
Palindromic rheumatism
Rheumatoid arthritis
ACPA
pre-RA
title_short Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
title_full Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
title_fullStr Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
title_full_unstemmed Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
title_sort Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
dc.creator.none.fl_str_mv Sanmartí, Raimon
Frade-Sosa, Beatriz
Morlà, Rosa
Castellanos-Moreira, Raul
Cabrero-Villalba, Sonia
Ramirez, Julio
Salvador, Georgina
Haro Villar, Isabel
Cañete, Juan D.
author Sanmartí, Raimon
author_facet Sanmartí, Raimon
Frade-Sosa, Beatriz
Morlà, Rosa
Castellanos-Moreira, Raul
Cabrero-Villalba, Sonia
Ramirez, Julio
Salvador, Georgina
Haro Villar, Isabel
Cañete, Juan D.
author_role author
author2 Frade-Sosa, Beatriz
Morlà, Rosa
Castellanos-Moreira, Raul
Cabrero-Villalba, Sonia
Ramirez, Julio
Salvador, Georgina
Haro Villar, Isabel
Cañete, Juan D.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Palindromic rheumatism
Rheumatoid arthritis
ACPA
pre-RA
topic Palindromic rheumatism
Rheumatoid arthritis
ACPA
pre-RA
description Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/235791
url http://hdl.handle.net/10261/235791
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3389/fmed.2021.657983
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419317881208832
score 15,812455

Similares en LA Referencia