Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review

In this review, recent advances over the past decade in the preparation of fluorinated stereogenic quaternary centers on β-keto esters compounds are analyzed. Since the incorporation of fluorine and fluorinated groups is of special interest in pharmaceutical chemistry, a range of metal-catalyzed and or...

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Detalhes bibliográficos
Autores: Granados, Albert|||0000-0002-5362-5966, Vallribera, Adelina|||0000-0002-6452-4589
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:233192
Acesso em linha:https://ddd.uab.cat/record/233192
https://dx.doi.org/urn:doi:10.3390/molecules25143264
Access Level:acceso abierto
Palavra-chave:Fluorination
Trifluoromethylation
Trifluoromethylthiolation
β-keto esters
Asymmetric
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spelling Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. ReviewGranados, Albert|||0000-0002-5362-5966Vallribera, Adelina|||0000-0002-6452-4589FluorinationTrifluoromethylationTrifluoromethylthiolationβ-keto estersAsymmetricIn this review, recent advances over the past decade in the preparation of fluorinated stereogenic quaternary centers on β-keto esters compounds are analyzed. Since the incorporation of fluorine and fluorinated groups is of special interest in pharmaceutical chemistry, a range of metal-catalyzed and organocatalyzed methods have been developed. Herein, we review the enantioselective fluorination, trifluoromethylation and trifluoromethylthiolation of 3-oxo esters. The scope, the induction of enantioselectivity and mechanistic investigations are presented. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/233192https://dx.doi.org/urn:doi:10.3390/molecules25143264reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 CTQ2016-81797-REDCMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 RED2018-102387-TAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-097853-B-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-0465open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2331922026-06-06T12:50:31Z
dc.title.none.fl_str_mv Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
title Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
spellingShingle Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
Granados, Albert|||0000-0002-5362-5966
Fluorination
Trifluoromethylation
Trifluoromethylthiolation
β-keto esters
Asymmetric
title_short Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
title_full Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
title_fullStr Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
title_full_unstemmed Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
title_sort Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
dc.creator.none.fl_str_mv Granados, Albert|||0000-0002-5362-5966
Vallribera, Adelina|||0000-0002-6452-4589
author Granados, Albert|||0000-0002-5362-5966
author_facet Granados, Albert|||0000-0002-5362-5966
Vallribera, Adelina|||0000-0002-6452-4589
author_role author
author2 Vallribera, Adelina|||0000-0002-6452-4589
author2_role author
dc.subject.none.fl_str_mv Fluorination
Trifluoromethylation
Trifluoromethylthiolation
β-keto esters
Asymmetric
topic Fluorination
Trifluoromethylation
Trifluoromethylthiolation
β-keto esters
Asymmetric
description In this review, recent advances over the past decade in the preparation of fluorinated stereogenic quaternary centers on β-keto esters compounds are analyzed. Since the incorporation of fluorine and fluorinated groups is of special interest in pharmaceutical chemistry, a range of metal-catalyzed and organocatalyzed methods have been developed. Herein, we review the enantioselective fluorination, trifluoromethylation and trifluoromethylthiolation of 3-oxo esters. The scope, the induction of enantioselectivity and mechanistic investigations are presented.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/233192
https://dx.doi.org/urn:doi:10.3390/molecules25143264
url https://ddd.uab.cat/record/233192
https://dx.doi.org/urn:doi:10.3390/molecules25143264
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CTQ2016-81797-REDC
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RED2018-102387-T
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-097853-B-I00
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-0465
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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