The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchows Triad

Portal vein thrombosis (PVT) is a common complication among patients with cirrhosis. However, its pathophysiology is not well established and there are currently very few predictive factors, none of which are actually useful, from a clinical perspective. The contribution of each of the vertices of V...

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Detalles Bibliográficos
Autores: Anton, Aina, Campreciós Figueras, Genís, Pérez Campuzano, Valeria, Orts, Lara, García Pagán, Juan Carlos, Hernández Gea, Virginia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/185770
Acceso en línea:https://hdl.handle.net/2445/185770
Access Level:acceso abierto
Palabra clave:Cirrosi hepàtica
Coagulació sanguínia
Trombosi
Endoteli
Vena porta
Circulació sanguínia
Hepatic cirrhosis
Blood coagulation
Thrombosis
Endothelium
Portal vein
Circulation of the blood
Descripción
Sumario:Portal vein thrombosis (PVT) is a common complication among patients with cirrhosis. However, its pathophysiology is not well established and there are currently very few predictive factors, none of which are actually useful, from a clinical perspective. The contribution of each of the vertices of Virchow's triad, e.g., blood hypercoagulability, blood flow, and portal vein endothelial damage in the development of PVT is not clear. In this review, we aim to recapitulate the latest studies on the field of PVT development in order to understand its mechanisms and discuss some of the future directions in the study of this important complication of cirrhosis.