Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study

The present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-week) interventions were combined in a randomized, co...

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Autores: Macià, Alba, Romero, María Paz, Yuste, Silvia, Ludwig, Iziar A., Pedret, Anna, Valls, Rosa-Maria, Salamanca, Patricia, Solá, Rosa, Motilva, María-José, Rubió, Laura
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/283865
Acceso en línea:http://hdl.handle.net/10261/283865
Access Level:acceso abierto
Palabra clave:Anthocyanins
Intake biomarkers
Metabolism
Red-fleshed apple
UPLC-MS/MS
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spelling Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR studyMacià, AlbaRomero, María PazYuste, SilviaLudwig, Iziar A.Pedret, AnnaValls, Rosa-MariaSalamanca, PatriciaSolá, RosaMotilva, María-JoséRubió, LauraAnthocyaninsIntake biomarkersMetabolismRed-fleshed appleUPLC-MS/MSThe present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-week) interventions were combined in a randomized, controlled and parallel study with 121 hypercholesterolemic subjects. Another arm consuming ACN-rich infusion from aronia fruit (ARO) provided matched content and profile of ACN. Plasma, urine and faeces samples were analyzed using UPLC-MS/MS. Results showed higher bioavailability of ACN after ARO compared to RFA, showing a clear apple matrix effect. The dihydrochalcone phloretin-2¿ -O-glucuronide was the most discriminant intake biomarker of both apples. The urinary peonidin-3-O-galactoside was a good biomarker after both ARO and RFA intakes, whereas peonidin-O-arabinoside was reported to be specific from ARO. The elucidation of the phenolic metabolism and the selection of intake biomarkers is a promising approach to relate phenolic compounds and human health.This study was supported by the Spanish Ministry of Industry, Economy and Competitiveness through the AGL2016-76943-C2-1-R and AGL2016-76943-C2-2-R projects (co-funded by the European Social Fund, European Union); M.J. Motilva thanks to Consejo Superior de Investigaciones Científicas-CSIC for partial funding throught the “Ayudas incorporacion ´ a escalas científicas CSIC, 2018” (Reference 201870I129). L.R. was Sara Borrell postdoctoral contract and she is a Serra Húnter Fellow. I.A.L. enjoys a post-doctoral contract (2017PMFPOST2-19) from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV). S.Y. was supported by a pre-doctoral grant from the University of Lleida. The authors are grateful to CALIDAD PASCUAL (Aranda de Duero, Burgos, Spain) for generously providing the Bezoya mineral water to prepare daily Aronia infusion.ElsevierMinisterio de Economía y Competitividad (España)European CommissionConsejo Superior de Investigaciones Científicas (España)Universidad de LleidaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/283865reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//AGL2016-76943-C2-1-Rinfo:eu-repo/grantAgreement/MINECO//AGL2016-76943-C2-2-RThe underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1016/j.foodchem.2022.132612http://dx.doi.org/10.1016/j.foodchem.2022.132612Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2838652026-05-22T06:33:51Z
dc.title.none.fl_str_mv Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
title Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
spellingShingle Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
Macià, Alba
Anthocyanins
Intake biomarkers
Metabolism
Red-fleshed apple
UPLC-MS/MS
title_short Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
title_full Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
title_fullStr Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
title_full_unstemmed Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
title_sort Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study
dc.creator.none.fl_str_mv Macià, Alba
Romero, María Paz
Yuste, Silvia
Ludwig, Iziar A.
Pedret, Anna
Valls, Rosa-Maria
Salamanca, Patricia
Solá, Rosa
Motilva, María-José
Rubió, Laura
author Macià, Alba
author_facet Macià, Alba
Romero, María Paz
Yuste, Silvia
Ludwig, Iziar A.
Pedret, Anna
Valls, Rosa-Maria
Salamanca, Patricia
Solá, Rosa
Motilva, María-José
Rubió, Laura
author_role author
author2 Romero, María Paz
Yuste, Silvia
Ludwig, Iziar A.
Pedret, Anna
Valls, Rosa-Maria
Salamanca, Patricia
Solá, Rosa
Motilva, María-José
Rubió, Laura
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Universidad de Lleida
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Anthocyanins
Intake biomarkers
Metabolism
Red-fleshed apple
UPLC-MS/MS
topic Anthocyanins
Intake biomarkers
Metabolism
Red-fleshed apple
UPLC-MS/MS
description The present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-week) interventions were combined in a randomized, controlled and parallel study with 121 hypercholesterolemic subjects. Another arm consuming ACN-rich infusion from aronia fruit (ARO) provided matched content and profile of ACN. Plasma, urine and faeces samples were analyzed using UPLC-MS/MS. Results showed higher bioavailability of ACN after ARO compared to RFA, showing a clear apple matrix effect. The dihydrochalcone phloretin-2¿ -O-glucuronide was the most discriminant intake biomarker of both apples. The urinary peonidin-3-O-galactoside was a good biomarker after both ARO and RFA intakes, whereas peonidin-O-arabinoside was reported to be specific from ARO. The elucidation of the phenolic metabolism and the selection of intake biomarkers is a promising approach to relate phenolic compounds and human health.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/283865
url http://hdl.handle.net/10261/283865
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//AGL2016-76943-C2-1-R
info:eu-repo/grantAgreement/MINECO//AGL2016-76943-C2-2-R
The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1016/j.foodchem.2022.132612
http://dx.doi.org/10.1016/j.foodchem.2022.132612
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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