Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study

We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) a...

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Autores: Benavente, Yolanda, Costas, Laura, Rodríguez Suárez, Marta María, Alguacil, Juan, Santibáñez, Miguel, Vila, Javier, Robles, Claudia, Alonso Sanz, Esther, Banda, Esmeralda de la, González Barca, Eva, Dierssen Sotos, Trinidad, Gimeno Vázquez, Eva, Aymerich Gregorio, Marta, Campo Güerri, Elias, Jiménez Moleón, José Juan, Marcos Gragera, Rafael, Castaño-Vinyals, Gemma, Aragonès Sanz, Núria, Pollan, Marina, Sanjosé Llongueras, Silvia de, Kogevinas, Manolis, Tardón, Adonina, Casabonne, Delphine
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/171743
Acceso en línea:https://hdl.handle.net/2445/171743
Access Level:acceso abierto
Palabra clave:Plaguicides
Leucèmia limfocítica crònica
Pesticides
Chronic lymphocytic leukemia
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spelling Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain StudyBenavente, YolandaCostas, LauraRodríguez Suárez, Marta MaríaAlguacil, JuanSantibáñez, MiguelVila, JavierRobles, ClaudiaAlonso Sanz, EstherBanda, Esmeralda de laGonzález Barca, EvaDierssen Sotos, TrinidadGimeno Vázquez, EvaAymerich Gregorio, MartaCampo Güerri, EliasJiménez Moleón, José JuanMarcos Gragera, RafaelCastaño-Vinyals, GemmaAragonès Sanz, NúriaPollan, MarinaSanjosé Llongueras, Silvia deKogevinas, ManolisTardón, AdoninaCasabonne, DelphinePlaguicidesLeucèmia limfocítica crònicaPesticidesChronic lymphocytic leukemiaWe aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010-2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/171743Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijerph17145174International Journal of Environmental Research and Public Health, 2020, vol. 17, num. 14https://doi.org/10.3390/ijerph17145174cc by (c) Benavente et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1717432026-05-27T06:46:51Z
dc.title.none.fl_str_mv Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
title Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
spellingShingle Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
Benavente, Yolanda
Plaguicides
Leucèmia limfocítica crònica
Pesticides
Chronic lymphocytic leukemia
title_short Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
title_full Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
title_fullStr Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
title_full_unstemmed Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
title_sort Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
dc.creator.none.fl_str_mv Benavente, Yolanda
Costas, Laura
Rodríguez Suárez, Marta María
Alguacil, Juan
Santibáñez, Miguel
Vila, Javier
Robles, Claudia
Alonso Sanz, Esther
Banda, Esmeralda de la
González Barca, Eva
Dierssen Sotos, Trinidad
Gimeno Vázquez, Eva
Aymerich Gregorio, Marta
Campo Güerri, Elias
Jiménez Moleón, José Juan
Marcos Gragera, Rafael
Castaño-Vinyals, Gemma
Aragonès Sanz, Núria
Pollan, Marina
Sanjosé Llongueras, Silvia de
Kogevinas, Manolis
Tardón, Adonina
Casabonne, Delphine
author Benavente, Yolanda
author_facet Benavente, Yolanda
Costas, Laura
Rodríguez Suárez, Marta María
Alguacil, Juan
Santibáñez, Miguel
Vila, Javier
Robles, Claudia
Alonso Sanz, Esther
Banda, Esmeralda de la
González Barca, Eva
Dierssen Sotos, Trinidad
Gimeno Vázquez, Eva
Aymerich Gregorio, Marta
Campo Güerri, Elias
Jiménez Moleón, José Juan
Marcos Gragera, Rafael
Castaño-Vinyals, Gemma
Aragonès Sanz, Núria
Pollan, Marina
Sanjosé Llongueras, Silvia de
Kogevinas, Manolis
Tardón, Adonina
Casabonne, Delphine
author_role author
author2 Costas, Laura
Rodríguez Suárez, Marta María
Alguacil, Juan
Santibáñez, Miguel
Vila, Javier
Robles, Claudia
Alonso Sanz, Esther
Banda, Esmeralda de la
González Barca, Eva
Dierssen Sotos, Trinidad
Gimeno Vázquez, Eva
Aymerich Gregorio, Marta
Campo Güerri, Elias
Jiménez Moleón, José Juan
Marcos Gragera, Rafael
Castaño-Vinyals, Gemma
Aragonès Sanz, Núria
Pollan, Marina
Sanjosé Llongueras, Silvia de
Kogevinas, Manolis
Tardón, Adonina
Casabonne, Delphine
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Plaguicides
Leucèmia limfocítica crònica
Pesticides
Chronic lymphocytic leukemia
topic Plaguicides
Leucèmia limfocítica crònica
Pesticides
Chronic lymphocytic leukemia
description We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010-2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/171743
url https://hdl.handle.net/2445/171743
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijerph17145174
International Journal of Environmental Research and Public Health, 2020, vol. 17, num. 14
https://doi.org/10.3390/ijerph17145174
dc.rights.none.fl_str_mv cc by (c) Benavente et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Benavente et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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