Pru p 3‐Epitope‐based sublingual immunotherapy in a murine model for the treatment of peach allergy

[Scope] Food‐specific immunotherapy (SIT) is a promising treatment for lipid transfer protein (LTP)‐syndrome. We propose a novel sublingual‐SIT (SLIT) that combines a Pru p 3 T‐cell peptide and an oligodeoxyribonucleotide (ODN) with CpG motifs (ODN‐CpG) as adjuvants to induce a specific Th1/Treg res...

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Detalhes bibliográficos
Autores: Rodriguez, Maria, J., Mascaraque, Ainhoa, Ramos-Soriano, Javier, Torres, María José, Perkins, James R., Gómez, Francisca, Garrido-Arandia, María, Cubells-Baeza, Nuria, Andreu, David, Díaz-Perales, Araceli, Rojo, Francisco Javier, Mayorga, Cristobalina
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/190522
Acesso em linha:http://hdl.handle.net/10261/190522
Access Level:acceso abierto
Palavra-chave:Anaphylaxis
Food‐allergy
Lipid transfer protein
Mouse model
Sublingual immunotherapy
Descrição
Resumo:[Scope] Food‐specific immunotherapy (SIT) is a promising treatment for lipid transfer protein (LTP)‐syndrome. We propose a novel sublingual‐SIT (SLIT) that combines a Pru p 3 T‐cell peptide and an oligodeoxyribonucleotide (ODN) with CpG motifs (ODN‐CpG) as adjuvants to induce a specific Th1/Treg response.

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