3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action

Thyroid hormones are involved in a complex arrangement of physiological and developmental responses in several tissues of higher vertebrates. Thyroxine, the main product of the thyroid gland, circulates in the blood stream being bouird either to specific plasma proteins (i.e. thyroxine binding globu...

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Detalles Bibliográficos
Autores: Brtko, Julius, Pascual, Ángel, Aranda, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1994
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/268241
Acceso en línea:http://hdl.handle.net/10261/268241
Access Level:acceso abierto
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repository_id_str
spelling 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone actionBrtko, JuliusPascual, ÁngelAranda, AnaThyroid hormones are involved in a complex arrangement of physiological and developmental responses in several tissues of higher vertebrates. Thyroxine, the main product of the thyroid gland, circulates in the blood stream being bouird either to specific plasma proteins (i.e. thyroxine binding globulin and transthyretin) or non-specifically to albumin. In the target tissue it is transported into the intracellular space by both the diffusion and energy dependent process (KRENNING et al. 198i). In the cytoplasmic space there is a "pool" of thyroid hormones containing the biologically active metabolite of thyroxine-3,5,3'-L-triiodothyronine (Tr) which originates from the monodeiodination of thyroxine. The T, enters the cell nucleus probably in the free form where it is specifically bound to nuclear receptors.Peer reviewedSlovak Academy of SciencesConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220221994info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/268241reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2682412026-05-22T06:33:51Z
dc.title.none.fl_str_mv 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
title 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
spellingShingle 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
Brtko, Julius
title_short 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
title_full 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
title_fullStr 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
title_full_unstemmed 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
title_sort 3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action
dc.creator.none.fl_str_mv Brtko, Julius
Pascual, Ángel
Aranda, Ana
author Brtko, Julius
author_facet Brtko, Julius
Pascual, Ángel
Aranda, Ana
author_role author
author2 Pascual, Ángel
Aranda, Ana
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Thyroid hormones are involved in a complex arrangement of physiological and developmental responses in several tissues of higher vertebrates. Thyroxine, the main product of the thyroid gland, circulates in the blood stream being bouird either to specific plasma proteins (i.e. thyroxine binding globulin and transthyretin) or non-specifically to albumin. In the target tissue it is transported into the intracellular space by both the diffusion and energy dependent process (KRENNING et al. 198i). In the cytoplasmic space there is a "pool" of thyroid hormones containing the biologically active metabolite of thyroxine-3,5,3'-L-triiodothyronine (Tr) which originates from the monodeiodination of thyroxine. The T, enters the cell nucleus probably in the free form where it is specifically bound to nuclear receptors.
publishDate 1994
dc.date.none.fl_str_mv 1994
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/268241
url http://hdl.handle.net/10261/268241
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Slovak Academy of Sciences
publisher.none.fl_str_mv Slovak Academy of Sciences
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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