3,5,3'-Triiodothyronine nuclear receptors and their role in the thyroid hormone action

Thyroid hormones are involved in a complex arrangement of physiological and developmental responses in several tissues of higher vertebrates. Thyroxine, the main product of the thyroid gland, circulates in the blood stream being bouird either to specific plasma proteins (i.e. thyroxine binding globu...

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Detalles Bibliográficos
Autores: Brtko, Julius, Pascual, Ángel, Aranda, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1994
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/268241
Acceso en línea:http://hdl.handle.net/10261/268241
Access Level:acceso abierto
Descripción
Sumario:Thyroid hormones are involved in a complex arrangement of physiological and developmental responses in several tissues of higher vertebrates. Thyroxine, the main product of the thyroid gland, circulates in the blood stream being bouird either to specific plasma proteins (i.e. thyroxine binding globulin and transthyretin) or non-specifically to albumin. In the target tissue it is transported into the intracellular space by both the diffusion and energy dependent process (KRENNING et al. 198i). In the cytoplasmic space there is a "pool" of thyroid hormones containing the biologically active metabolite of thyroxine-3,5,3'-L-triiodothyronine (Tr) which originates from the monodeiodination of thyroxine. The T, enters the cell nucleus probably in the free form where it is specifically bound to nuclear receptors.

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