Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
Malaltia d'Alzheimer; Apolipoproteïnes; Angiopatia amiloide cerebral
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/6002 |
| Acceso en línea: | https://hdl.handle.net/11351/6002 http://hdl.handle.net/11351/6002 |
| Access Level: | acceso abierto |
| Palabra clave: | Cervell - Malalties Lipoproteïnes de la sang - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Lipoproteins Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::lipoproteínas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| id |
ES_c813bf8dbcd5a16bd76ca3e7ad06af50 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:11351/6002 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
| title |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
| spellingShingle |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease Bonaterra Pastra, Anna Cervell - Malalties Lipoproteïnes de la sang - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Lipoproteins Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::lipoproteínas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| title_short |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
| title_full |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
| title_fullStr |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
| title_full_unstemmed |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
| title_sort |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
| dc.creator.none.fl_str_mv |
Bonaterra Pastra, Anna Fernández de Retana, Sofía Rivas-Urbina, Andrea Puig, Núria Benítez, Sònia Pancorbo Rosal, Olalla Rodriguez Luna, David Pujadas Navinés, Francesc Montaner Villalonga, Joan Hernandez Guillamon, Maria Mar |
| author |
Bonaterra Pastra, Anna |
| author_facet |
Bonaterra Pastra, Anna Fernández de Retana, Sofía Rivas-Urbina, Andrea Puig, Núria Benítez, Sònia Pancorbo Rosal, Olalla Rodriguez Luna, David Pujadas Navinés, Francesc Montaner Villalonga, Joan Hernandez Guillamon, Maria Mar |
| author_role |
author |
| author2 |
Fernández de Retana, Sofía Rivas-Urbina, Andrea Puig, Núria Benítez, Sònia Pancorbo Rosal, Olalla Rodriguez Luna, David Pujadas Navinés, Francesc Montaner Villalonga, Joan Hernandez Guillamon, Maria Mar |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Bonaterra-Pastra A, Fernández-de-Retana S, Hernández-Guillamon M] Laboratori de recerca neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rivas-Urbina A, Puig N, Benítez S] Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau (IIB Sant Pau), Barcelona, Spain. [Pancorbo O, Rodríguez-Luna D] Grup de Recerca en Ictus, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Pujadas F] Unitat de Demència, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Montaner J] Laboratori de recerca neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Stroke Unit, Virgen del Rocío University Hospital, Sevilla, Spain. Department of Neurology, Virgen Macarena University Hospital, Sevilla, Spain. Stroke Research Program, Institute of Biomedicine of Sevilla, IBiS, Sevilla, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Cervell - Malalties Lipoproteïnes de la sang - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Lipoproteins Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::lipoproteínas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| topic |
Cervell - Malalties Lipoproteïnes de la sang - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Lipoproteins Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::lipoproteínas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| description |
Malaltia d'Alzheimer; Apolipoproteïnes; Angiopatia amiloide cerebral |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/6002 http://hdl.handle.net/11351/6002 |
| url |
https://hdl.handle.net/11351/6002 http://hdl.handle.net/11351/6002 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Biomedicines;9(1) https://doi.org/10.3390/biomedicines9010072 info:eu-repo/grantAgreement/ES/PE2013-2016/PI13%2F00364 info:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00471 info:eu-repo/grantAgreement/ES/PE2013-2016/PI14%2F01134 info:eu-repo/grantAgreement/ES/PE2013-2016/PI17%2F00275 info:eu-repo/grantAgreement/ES/PE2013-2016/FI17%2F00031 info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0019%2F0021 info:eu-repo/grantAgreement/ES/PE2013-2016/CPII17%2F00010 info:eu-repo/grantAgreement/ES/PERIS2016-2020/2017-SGR-1149 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869419233589329920 |
| spelling |
Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s DiseaseBonaterra Pastra, AnnaFernández de Retana, SofíaRivas-Urbina, AndreaPuig, NúriaBenítez, SòniaPancorbo Rosal, OlallaRodriguez Luna, DavidPujadas Navinés, FrancescMontaner Villalonga, JoanHernandez Guillamon, Maria MarCervell - MalaltiesLipoproteïnes de la sang - MetabolismeDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain DiseasesCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::LipoproteinsOther subheadings::Other subheadings::Other subheadings::/metabolismENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebralesCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::lipoproteínasOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoMalaltia d'Alzheimer; Apolipoproteïnes; Angiopatia amiloide cerebralEnfermedad de Alzheimer; Apolipoproteínas; Angiopatía amiloide cerebralAlzheimer’s disease; Apolipoproteins; Cerebral amyloid angiopathyCerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer’s disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.This research was funded by Instituto de Salud Carlos III (co-financed by the European Regional Development Fund FEDER “Una manera de hacer Europa”), grant numbers PI13/00364, PI16/00471, PI14/01134 and PI17/00275. A.R.-U. was funded by Instituto de Salud Carlos III predoctoral contract FI17/00031. The Neurovascular Research Laboratory is part of the INVICTUS+ network, ISCIII, Spain [RD16/0019/0021]. J.L.S.-Q. is a member of the CIBER of Diabetes and Metabolism (CIBERDEM), ISCIII, Spain. M.H.-G. is supported by the Miguel Servet programme, ISCIII, Spain [CPII17/00010]. A.R.-U., N.P., S.B. and J.L.S.-Q. are members of the Quality Research Group 2017-SGR-1149 from Generalitat de Catalunya. A.R.-U., N.P., S.B. and J.L.S.-Q. are members of the Group of Vascular Biology from the Spanish Atherosclerosis Society.MDPIInstitut Català de la Salut[Bonaterra-Pastra A, Fernández-de-Retana S, Hernández-Guillamon M] Laboratori de recerca neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rivas-Urbina A, Puig N, Benítez S] Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau (IIB Sant Pau), Barcelona, Spain. [Pancorbo O, Rodríguez-Luna D] Grup de Recerca en Ictus, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Pujadas F] Unitat de Demència, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Montaner J] Laboratori de recerca neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Stroke Unit, Virgen del Rocío University Hospital, Sevilla, Spain. Department of Neurology, Virgen Macarena University Hospital, Sevilla, Spain. Stroke Research Program, Institute of Biomedicine of Sevilla, IBiS, Sevilla, SpainVall d'Hebron Barcelona Hospital Campus202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6002http://hdl.handle.net/11351/6002Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBiomedicines;9(1)https://doi.org/10.3390/biomedicines9010072info:eu-repo/grantAgreement/ES/PE2013-2016/PI13%2F00364info:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00471info:eu-repo/grantAgreement/ES/PE2013-2016/PI14%2F01134info:eu-repo/grantAgreement/ES/PE2013-2016/PI17%2F00275info:eu-repo/grantAgreement/ES/PE2013-2016/FI17%2F00031info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0019%2F0021info:eu-repo/grantAgreement/ES/PE2013-2016/CPII17%2F00010info:eu-repo/grantAgreement/ES/PERIS2016-2020/2017-SGR-1149Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/60022026-05-29T05:05:01Z |
| score |
15.812429 |