Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals
Background: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis of Parkinson's disease (PD). Objective: To investigate potential oculomotor differences between idiopathic PD...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/33547 |
| Acceso en línea: | https://hdl.handle.net/10902/33547 |
| Access Level: | acceso abierto |
| Palabra clave: | Parkinson's disease LRRK2 Oculomotor Early diagnosis Premotor Microsaccade Antisaccade Eye-tracking |
| id |
ES_c811bdfb83a9903230f332cd3b5f5bcf |
|---|---|
| oai_identifier_str |
oai:repositorio.unican.es:10902/33547 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individualsLage Martínez, CarmenSánchez-Rodríguez, AntonioRivera-Sánchez, MaríaSierra Peña, MaríaGonzález Aramburu, IsabelMadera Fernández, JorgeDelgado Alvarado, ManuelLópez García, SaraMartínez Dubarbie, FranciscoFernández Matarrubia, MartaMartínez-Amador, NéstorMartínez Rodríguez, Mª IsabelCalvo-Córdoba, AlbertoRodríguez Rodríguez, Eloy ManuelGarcía-Cena, CeciliaSánchez-Juan, Pascual|||0000-0002-6081-8037Infante Ceberio, Jon|||0000-0003-4025-4606Parkinson's diseaseLRRK2OculomotorEarly diagnosisPremotorMicrosaccadeAntisaccadeEye-trackingBackground: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis of Parkinson's disease (PD). Objective: To investigate potential oculomotor differences between idiopathic PD (iPD) and PD associated with the G2019S variant of LRRK2 (L2PD), as well as to evaluate oculomotor function in asymptomatic carriers of the G2019S variant of LRRK2. Methods: The study enrolled 129 subjects: 30 PD (16 iPD, 14 L2PD), 23 asymptomatic carriers, 13 non-carrier relatives of L2PD patients, and 63 unrelated HCs. The video-oculographic evaluation included fixation, prosaccade, antisaccade, and memory saccade tests. Results: We did not find significant differences between iPD and L2PD. Compared to controls, PD patients displayed widespread oculomotor deficits including larger microsaccades, hypometric vertical prosaccades, increased latencies in all tests, and lower percentages of successful antisaccades and memory saccades. Non-carrier relatives showed oculomotor changes with parkinsonian features, such as fixation instability and hypometric vertical saccades. Asymptomatic carriers shared multiple similarities with PD, including signs of unstable fixation and hypometric vertical prosaccades; however, they were able to reach percentages of successful antisaccade and memory saccades similar to controls, although at the expense of longer latencies. Classification accuracy of significant oculomotor parameters to differentiate asymptomatic carriers from HCs ranged from 0.68 to 0.74, with BCEA, a marker of global fixation instability, being the parameter with the greatest classification accuracy. Conclusions: iPD and LRRK2-G2019S PD patients do not seem to display a differential oculomotor profile. Several oculomotor changes in asymptomatic carriers of LRRK2 mutations could be considered premotor biomarkers.IOS PressUniversidad de Cantabria20242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/33547Journal of Parkinson's Disease, 2024, 14, 797-808reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/335472026-06-02T12:39:31Z |
| dc.title.none.fl_str_mv |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals |
| title |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals |
| spellingShingle |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals Lage Martínez, Carmen Parkinson's disease LRRK2 Oculomotor Early diagnosis Premotor Microsaccade Antisaccade Eye-tracking |
| title_short |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals |
| title_full |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals |
| title_fullStr |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals |
| title_full_unstemmed |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals |
| title_sort |
Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals |
| dc.creator.none.fl_str_mv |
Lage Martínez, Carmen Sánchez-Rodríguez, Antonio Rivera-Sánchez, María Sierra Peña, María González Aramburu, Isabel Madera Fernández, Jorge Delgado Alvarado, Manuel López García, Sara Martínez Dubarbie, Francisco Fernández Matarrubia, Marta Martínez-Amador, Néstor Martínez Rodríguez, Mª Isabel Calvo-Córdoba, Alberto Rodríguez Rodríguez, Eloy Manuel García-Cena, Cecilia Sánchez-Juan, Pascual|||0000-0002-6081-8037 Infante Ceberio, Jon|||0000-0003-4025-4606 |
| author |
Lage Martínez, Carmen |
| author_facet |
Lage Martínez, Carmen Sánchez-Rodríguez, Antonio Rivera-Sánchez, María Sierra Peña, María González Aramburu, Isabel Madera Fernández, Jorge Delgado Alvarado, Manuel López García, Sara Martínez Dubarbie, Francisco Fernández Matarrubia, Marta Martínez-Amador, Néstor Martínez Rodríguez, Mª Isabel Calvo-Córdoba, Alberto Rodríguez Rodríguez, Eloy Manuel García-Cena, Cecilia Sánchez-Juan, Pascual|||0000-0002-6081-8037 Infante Ceberio, Jon|||0000-0003-4025-4606 |
| author_role |
author |
| author2 |
Sánchez-Rodríguez, Antonio Rivera-Sánchez, María Sierra Peña, María González Aramburu, Isabel Madera Fernández, Jorge Delgado Alvarado, Manuel López García, Sara Martínez Dubarbie, Francisco Fernández Matarrubia, Marta Martínez-Amador, Néstor Martínez Rodríguez, Mª Isabel Calvo-Córdoba, Alberto Rodríguez Rodríguez, Eloy Manuel García-Cena, Cecilia Sánchez-Juan, Pascual|||0000-0002-6081-8037 Infante Ceberio, Jon|||0000-0003-4025-4606 |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Parkinson's disease LRRK2 Oculomotor Early diagnosis Premotor Microsaccade Antisaccade Eye-tracking |
| topic |
Parkinson's disease LRRK2 Oculomotor Early diagnosis Premotor Microsaccade Antisaccade Eye-tracking |
| description |
Background: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis of Parkinson's disease (PD). Objective: To investigate potential oculomotor differences between idiopathic PD (iPD) and PD associated with the G2019S variant of LRRK2 (L2PD), as well as to evaluate oculomotor function in asymptomatic carriers of the G2019S variant of LRRK2. Methods: The study enrolled 129 subjects: 30 PD (16 iPD, 14 L2PD), 23 asymptomatic carriers, 13 non-carrier relatives of L2PD patients, and 63 unrelated HCs. The video-oculographic evaluation included fixation, prosaccade, antisaccade, and memory saccade tests. Results: We did not find significant differences between iPD and L2PD. Compared to controls, PD patients displayed widespread oculomotor deficits including larger microsaccades, hypometric vertical prosaccades, increased latencies in all tests, and lower percentages of successful antisaccades and memory saccades. Non-carrier relatives showed oculomotor changes with parkinsonian features, such as fixation instability and hypometric vertical saccades. Asymptomatic carriers shared multiple similarities with PD, including signs of unstable fixation and hypometric vertical prosaccades; however, they were able to reach percentages of successful antisaccade and memory saccades similar to controls, although at the expense of longer latencies. Classification accuracy of significant oculomotor parameters to differentiate asymptomatic carriers from HCs ranged from 0.68 to 0.74, with BCEA, a marker of global fixation instability, being the parameter with the greatest classification accuracy. Conclusions: iPD and LRRK2-G2019S PD patients do not seem to display a differential oculomotor profile. Several oculomotor changes in asymptomatic carriers of LRRK2 mutations could be considered premotor biomarkers. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10902/33547 |
| url |
https://hdl.handle.net/10902/33547 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
IOS Press |
| publisher.none.fl_str_mv |
IOS Press |
| dc.source.none.fl_str_mv |
Journal of Parkinson's Disease, 2024, 14, 797-808 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
| instname_str |
Universidad de Cantabria (UC) |
| reponame_str |
UCrea Repositorio Abierto de la Universidad de Cantabria |
| collection |
UCrea Repositorio Abierto de la Universidad de Cantabria |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869419233031487488 |
| score |
15,812429 |