Depression in Major Neurodegenerative Diseases and Strokes

Depression and anxiety are highly prevalent in most neurological disorders and can have a major impact on the patient's disability and quality of life. However, mostly due to the heterogeneity of symptoms and the complexity of the underlying comorbidities, depression can be difficult to diagnos...

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Autores: Pagonabarraga Mora, Javier|||0000-0002-3248-704X, Álamo, Cecilio|||0000-0001-7652-7931, Castellanos, María del Mar|||0000-0003-3116-1352, Díaz-Insa, Samuel|||0000-0001-9479-2325, Manzano, Sagrario|||0000-0002-4152-1633
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:273061
Acceso en línea:https://ddd.uab.cat/record/273061
https://dx.doi.org/urn:doi:10.3390/brainsci13020318
Access Level:acceso abierto
Palabra clave:Depression
Dementia
Alzheimer's disease
Parkinson's disease
Stroke
SSRIs
SNRIs
Vortioxetine
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spelling Depression in Major Neurodegenerative Diseases and StrokesA Critical Review of Similarities and Differences among Neurological DisordersPagonabarraga Mora, Javier|||0000-0002-3248-704XÁlamo, Cecilio|||0000-0001-7652-7931Castellanos, María del Mar|||0000-0003-3116-1352Díaz-Insa, Samuel|||0000-0001-9479-2325Manzano, Sagrario|||0000-0002-4152-1633DepressionDementiaAlzheimer's diseaseParkinson's diseaseStrokeSSRIsSNRIsVortioxetineDepression and anxiety are highly prevalent in most neurological disorders and can have a major impact on the patient's disability and quality of life. However, mostly due to the heterogeneity of symptoms and the complexity of the underlying comorbidities, depression can be difficult to diagnose, resulting in limited recognition and in undertreatment. The early detection and treatment of depression simultaneously with the neurological disorder is key to avoiding deterioration and further disability. Although the neurologist should be able to identify and treat depression initially, a neuropsychiatry team should be available for severe cases and those who are unresponsive to treatment. Neurologists should be also aware that in neurodegenerative diseases, such as Alzheimer's or Parkinson's, different depression symptoms could develop at different stages of the disease. The treatment options for depression in neurological diseases include drugs, cognitive-behavioral therapy, and somatic interventions, among others, but often, the evidence-based efficacy is limited and the results are highly variable. Here, we review recent research on the diagnosis and treatment of depression in the context of Alzheimer's disease, Parkinson's disease, and strokes, with the aim of identifying common approaches and solutions for its initial management by the neurologist. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/273061https://dx.doi.org/urn:doi:10.3390/brainsci13020318reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2730612026-06-06T12:50:31Z
dc.title.none.fl_str_mv Depression in Major Neurodegenerative Diseases and Strokes
A Critical Review of Similarities and Differences among Neurological Disorders
title Depression in Major Neurodegenerative Diseases and Strokes
spellingShingle Depression in Major Neurodegenerative Diseases and Strokes
Pagonabarraga Mora, Javier|||0000-0002-3248-704X
Depression
Dementia
Alzheimer's disease
Parkinson's disease
Stroke
SSRIs
SNRIs
Vortioxetine
title_short Depression in Major Neurodegenerative Diseases and Strokes
title_full Depression in Major Neurodegenerative Diseases and Strokes
title_fullStr Depression in Major Neurodegenerative Diseases and Strokes
title_full_unstemmed Depression in Major Neurodegenerative Diseases and Strokes
title_sort Depression in Major Neurodegenerative Diseases and Strokes
dc.creator.none.fl_str_mv Pagonabarraga Mora, Javier|||0000-0002-3248-704X
Álamo, Cecilio|||0000-0001-7652-7931
Castellanos, María del Mar|||0000-0003-3116-1352
Díaz-Insa, Samuel|||0000-0001-9479-2325
Manzano, Sagrario|||0000-0002-4152-1633
author Pagonabarraga Mora, Javier|||0000-0002-3248-704X
author_facet Pagonabarraga Mora, Javier|||0000-0002-3248-704X
Álamo, Cecilio|||0000-0001-7652-7931
Castellanos, María del Mar|||0000-0003-3116-1352
Díaz-Insa, Samuel|||0000-0001-9479-2325
Manzano, Sagrario|||0000-0002-4152-1633
author_role author
author2 Álamo, Cecilio|||0000-0001-7652-7931
Castellanos, María del Mar|||0000-0003-3116-1352
Díaz-Insa, Samuel|||0000-0001-9479-2325
Manzano, Sagrario|||0000-0002-4152-1633
author2_role author
author
author
author
dc.subject.none.fl_str_mv Depression
Dementia
Alzheimer's disease
Parkinson's disease
Stroke
SSRIs
SNRIs
Vortioxetine
topic Depression
Dementia
Alzheimer's disease
Parkinson's disease
Stroke
SSRIs
SNRIs
Vortioxetine
description Depression and anxiety are highly prevalent in most neurological disorders and can have a major impact on the patient's disability and quality of life. However, mostly due to the heterogeneity of symptoms and the complexity of the underlying comorbidities, depression can be difficult to diagnose, resulting in limited recognition and in undertreatment. The early detection and treatment of depression simultaneously with the neurological disorder is key to avoiding deterioration and further disability. Although the neurologist should be able to identify and treat depression initially, a neuropsychiatry team should be available for severe cases and those who are unresponsive to treatment. Neurologists should be also aware that in neurodegenerative diseases, such as Alzheimer's or Parkinson's, different depression symptoms could develop at different stages of the disease. The treatment options for depression in neurological diseases include drugs, cognitive-behavioral therapy, and somatic interventions, among others, but often, the evidence-based efficacy is limited and the results are highly variable. Here, we review recent research on the diagnosis and treatment of depression in the context of Alzheimer's disease, Parkinson's disease, and strokes, with the aim of identifying common approaches and solutions for its initial management by the neurologist.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/273061
https://dx.doi.org/urn:doi:10.3390/brainsci13020318
url https://ddd.uab.cat/record/273061
https://dx.doi.org/urn:doi:10.3390/brainsci13020318
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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