Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose

Consumption of high-energy-yielding diets, rich in fructose and lipids, is a factor contributing to the current increase in non-alcoholic fatty liver disease prevalence. Gut microbiota composition and short-chain fatty acids (SCFAs) production alterations derived from unhealthy diets are considered...

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Autores: Milton Laskibar, Iñaki, Marcos Zambrano, Laura Judith, Gómez Zorita, Saioa, Carrillo de Santa Pau, Enrique, Fernández Quintela, Alfredo, Martínez Hernández, José Alfredo, Portillo Baquedano, María Puy
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/66933
Acceso en línea:http://hdl.handle.net/10810/66933
Access Level:acceso abierto
Palabra clave:non-alcoholic steatohepatitis
rat
microbiota
high-fat high-fructose diet
short-chain fatty acids
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spelling Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructoseMilton Laskibar, IñakiMarcos Zambrano, Laura JudithGómez Zorita, SaioaCarrillo de Santa Pau, EnriqueFernández Quintela, AlfredoMartínez Hernández, José AlfredoPortillo Baquedano, María Puynon-alcoholic steatohepatitisratmicrobiotahigh-fat high-fructose dietshort-chain fatty acidsConsumption of high-energy-yielding diets, rich in fructose and lipids, is a factor contributing to the current increase in non-alcoholic fatty liver disease prevalence. Gut microbiota composition and short-chain fatty acids (SCFAs) production alterations derived from unhealthy diets are considered putative underlying mechanisms. This study aimed to determine relationships between changes in gut microbiota composition and SCFA levels by comparing rats featuring diet-induced steatohepatitis with control counterparts fed a standard diet. A high-fat high-fructose (HFHF) feeding induced higher body, liver and mesenteric adipose tissue weights, increased liver triglyceride content and serum transaminase, glucose, non-HDL-c and MCP-1 levels. Greater liver malondialdehyde levels and glutathione peroxidase activity were also observed after feeding the hypercaloric diet. Regarding gut microbiota composition, a lowered diversity and increased abundances of bacteria from the Clostridium sensu stricto 1, Blautia, Eubacterium coprostanoligenes group, Flavonifractor, and UBA1819 genera were found in rats featuring diet-induced steatohepatitis, as well as higher isobutyric, valeric and isovaleric acids concentrations. These results suggest that hepatic alterations produced by a hypercaloric HFHF diet may be related to changes in overall gut microbiota composition and abundance of specific bacteria. The shift in SCFA levels produced by this unbalanced diet cannot be discarded as potential mediators of the reported hepatic and metabolic alterations.I.M.-L. acknowledges financial support from the Juan de la Cierva Programme-Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2019-038925-I). L.J.M.-Z. has a Juan de la Cierva Grant (IJC2019-042188-I) from the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades. This research was funded by the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (grant number AGL-2015-65719-R MINECO/FEDER, UE), Instituto de Salud Carlos III CIBERobn (grant number CB12/03/30007) and University of the Basque Country (grant number GIU 18/173).Cambridge University Press202420242022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/66933reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/FJC2019-038925-I/info:eu-repo/grantAgreement/MICIU/IJC2019-042188-I/https://www.cambridge.org/core/journals/gut-microbiome/article/involvement-of-microbiota-and-shortchain-fatty-acids-on-nonalcoholic-steatohepatitis-when-induced-by-feeding-a-hypercaloric-diet-rich-in-saturated-fat-and-fructose/9B9899B87CAC62F834BA48B7960DF526info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly citedAtribución 3.0 Españaoai:addi.ehu.eus:10810/669332026-06-18T09:23:17Z
dc.title.none.fl_str_mv Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
title Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
spellingShingle Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
Milton Laskibar, Iñaki
non-alcoholic steatohepatitis
rat
microbiota
high-fat high-fructose diet
short-chain fatty acids
title_short Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
title_full Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
title_fullStr Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
title_full_unstemmed Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
title_sort Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
dc.creator.none.fl_str_mv Milton Laskibar, Iñaki
Marcos Zambrano, Laura Judith
Gómez Zorita, Saioa
Carrillo de Santa Pau, Enrique
Fernández Quintela, Alfredo
Martínez Hernández, José Alfredo
Portillo Baquedano, María Puy
author Milton Laskibar, Iñaki
author_facet Milton Laskibar, Iñaki
Marcos Zambrano, Laura Judith
Gómez Zorita, Saioa
Carrillo de Santa Pau, Enrique
Fernández Quintela, Alfredo
Martínez Hernández, José Alfredo
Portillo Baquedano, María Puy
author_role author
author2 Marcos Zambrano, Laura Judith
Gómez Zorita, Saioa
Carrillo de Santa Pau, Enrique
Fernández Quintela, Alfredo
Martínez Hernández, José Alfredo
Portillo Baquedano, María Puy
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv non-alcoholic steatohepatitis
rat
microbiota
high-fat high-fructose diet
short-chain fatty acids
topic non-alcoholic steatohepatitis
rat
microbiota
high-fat high-fructose diet
short-chain fatty acids
description Consumption of high-energy-yielding diets, rich in fructose and lipids, is a factor contributing to the current increase in non-alcoholic fatty liver disease prevalence. Gut microbiota composition and short-chain fatty acids (SCFAs) production alterations derived from unhealthy diets are considered putative underlying mechanisms. This study aimed to determine relationships between changes in gut microbiota composition and SCFA levels by comparing rats featuring diet-induced steatohepatitis with control counterparts fed a standard diet. A high-fat high-fructose (HFHF) feeding induced higher body, liver and mesenteric adipose tissue weights, increased liver triglyceride content and serum transaminase, glucose, non-HDL-c and MCP-1 levels. Greater liver malondialdehyde levels and glutathione peroxidase activity were also observed after feeding the hypercaloric diet. Regarding gut microbiota composition, a lowered diversity and increased abundances of bacteria from the Clostridium sensu stricto 1, Blautia, Eubacterium coprostanoligenes group, Flavonifractor, and UBA1819 genera were found in rats featuring diet-induced steatohepatitis, as well as higher isobutyric, valeric and isovaleric acids concentrations. These results suggest that hepatic alterations produced by a hypercaloric HFHF diet may be related to changes in overall gut microbiota composition and abundance of specific bacteria. The shift in SCFA levels produced by this unbalanced diet cannot be discarded as potential mediators of the reported hepatic and metabolic alterations.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/66933
url http://hdl.handle.net/10810/66933
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/FJC2019-038925-I/
info:eu-repo/grantAgreement/MICIU/IJC2019-042188-I/
https://www.cambridge.org/core/journals/gut-microbiome/article/involvement-of-microbiota-and-shortchain-fatty-acids-on-nonalcoholic-steatohepatitis-when-induced-by-feeding-a-hypercaloric-diet-rich-in-saturated-fat-and-fructose/9B9899B87CAC62F834BA48B7960DF526
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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