Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging

We describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with an almost spherical shape and a mean size of ∼60 nm and their functionalization with poly(acrylic acid). The transverse magnetic relaxivity of...

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Autores: Gómez Gónzalez, Elisabet, Núñez, Nuria O., Caro, Carlos, García-Martín, María L., Fernández-Afonso, Yilian, Fuente, Jesús M. de la, Balcerzyk, Marcin, Ocaña, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/140771
Acceso en línea:https://hdl.handle.net/11441/140771
https://doi.org/10.1021/acs.inorgchem.0c02601
Access Level:acceso abierto
Palabra clave:Functionalization
Magnetic properties
Nanoparticles
Physical and chemical processes
X-rays
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spelling Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography ImagingGómez Gónzalez, ElisabetNúñez, Nuria O.Caro, CarlosGarcía-Martín, María L.Fernández-Afonso, YilianFuente, Jesús M. de laBalcerzyk, MarcinOcaña, ManuelFunctionalizationMagnetic propertiesNanoparticlesPhysical and chemical processesX-raysWe describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with an almost spherical shape and a mean size of ∼60 nm and their functionalization with poly(acrylic acid). The transverse magnetic relaxivity of both systems at 9.4 T is analyzed on the basis of magnetic susceptibility and magnetization measurements in order to evaluate their potential for application as high-field MRI contrast agents. In addition, the X-ray attenuation properties of these systems are also studied to determine their capabilities as computed tomography contrast agent. Finally, the colloidal stability under physiological pH conditions and the cytotoxicity of the functionalized NPs are also addressed to assess their suitability for bioimaging applications.ACS PublicationasFisiología Médica y BiofísicaMinisterio de Ciencia, Innovación y Universidades (MICINN). España RTI2018-094426–B-I00; BIO2017-84246-C2-1-RGobierno de Aragón2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/140771https://doi.org/10.1021/acs.inorgchem.0c02601reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInorganic Chemistry, 60 (1), 152-160.RTI2018-094426–B-I00BIO2017-84246-C2-1-Rhttps://pubs.acs.org/doi/10.1021/acs.inorgchem.0c02601info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1407712026-06-17T12:51:07Z
dc.title.none.fl_str_mv Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
title Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
spellingShingle Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
Gómez Gónzalez, Elisabet
Functionalization
Magnetic properties
Nanoparticles
Physical and chemical processes
X-rays
title_short Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
title_full Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
title_fullStr Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
title_full_unstemmed Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
title_sort Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
dc.creator.none.fl_str_mv Gómez Gónzalez, Elisabet
Núñez, Nuria O.
Caro, Carlos
García-Martín, María L.
Fernández-Afonso, Yilian
Fuente, Jesús M. de la
Balcerzyk, Marcin
Ocaña, Manuel
author Gómez Gónzalez, Elisabet
author_facet Gómez Gónzalez, Elisabet
Núñez, Nuria O.
Caro, Carlos
García-Martín, María L.
Fernández-Afonso, Yilian
Fuente, Jesús M. de la
Balcerzyk, Marcin
Ocaña, Manuel
author_role author
author2 Núñez, Nuria O.
Caro, Carlos
García-Martín, María L.
Fernández-Afonso, Yilian
Fuente, Jesús M. de la
Balcerzyk, Marcin
Ocaña, Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
Ministerio de Ciencia, Innovación y Universidades (MICINN). España RTI2018-094426–B-I00; BIO2017-84246-C2-1-R
Gobierno de Aragón
dc.subject.none.fl_str_mv Functionalization
Magnetic properties
Nanoparticles
Physical and chemical processes
X-rays
topic Functionalization
Magnetic properties
Nanoparticles
Physical and chemical processes
X-rays
description We describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with an almost spherical shape and a mean size of ∼60 nm and their functionalization with poly(acrylic acid). The transverse magnetic relaxivity of both systems at 9.4 T is analyzed on the basis of magnetic susceptibility and magnetization measurements in order to evaluate their potential for application as high-field MRI contrast agents. In addition, the X-ray attenuation properties of these systems are also studied to determine their capabilities as computed tomography contrast agent. Finally, the colloidal stability under physiological pH conditions and the cytotoxicity of the functionalized NPs are also addressed to assess their suitability for bioimaging applications.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/140771
https://doi.org/10.1021/acs.inorgchem.0c02601
url https://hdl.handle.net/11441/140771
https://doi.org/10.1021/acs.inorgchem.0c02601
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Inorganic Chemistry, 60 (1), 152-160.
RTI2018-094426–B-I00
BIO2017-84246-C2-1-R
https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c02601
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ACS Publicationas
publisher.none.fl_str_mv ACS Publicationas
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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