Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis

Aims. This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab. Materials & methods: Prospective observational study evaluating the association of 124 polymorphisms with the response to adalimumab or infliximab (PASI75) in patient...

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Detalles Bibliográficos
Autores: Ovejero-Benito, María C., Prieto-Pérez, Rocío, Llamas Velasco, María del Mar, Muñoz-Aceituno, Ester, Reolid, Alejandra, Saiz-Rodríguez, Miriam, Belmonte, Carmen, Román, Manuel, Ochoa Mazarro, María Dolores, Talegón, María, Cabaleiro, Teresa, Daudén Tello, Esteban, Abad Santos, Francisco
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/684692
Acceso en línea:http://hdl.handle.net/10486/684692
https://dx.doi.org/10.2217/pgs-2017-0143
Access Level:acceso abierto
Palabra clave:Adalimumab
Anti-TNF drugs
Infliximab
Pharmacogenetics
Psoriasis
Farmacia
Descripción
Sumario:Aims. This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab. Materials & methods: Prospective observational study evaluating the association of 124 polymorphisms with the response to adalimumab or infliximab (PASI75) in patients with moderate-to-severe plaque psoriasis at 3 months (n = 95) and 6 months of treatment (n = 90). Significant SNPs for univariate analysis were subjected to multivariate analysis. Results: Five SNPs were associated with PASI75 at 3 months: rs6661932 (IVL), rs2546890 (IL-12B), rs2145623 (NFKBIA), rs9304742 (ZNF816A) and rs645544 (SLC9A8). Furthermore, rs1061624 (TNFR1B) was associated with PASI75 at 6 months. Conclusion: Nevertheless, these biomarkers should be validated in large-scale studies before implementation in clinical practice.

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