Allogeneic Stem Cell Transplantation with CD34+ Cell Selection

The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promisi...

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Autores: Roldan, Elisa, Perales, Miguel Angel, Barba, Pere|||0000-0001-7076-7969
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:249795
Acceso en línea:https://ddd.uab.cat/record/249795
https://dx.doi.org/urn:doi:10.2991/chi.d.190613.001
Access Level:acceso abierto
Palabra clave:Allogeneic transplant
Graft- versus -host disease
T cell depletion
CD34+ cell selection
Graft- versus -host disease-free and relapse-free survival (GRFS)
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spelling Allogeneic Stem Cell Transplantation with CD34+ Cell SelectionRoldan, ElisaPerales, Miguel AngelBarba, Pere|||0000-0001-7076-7969Allogeneic transplantGraft- versus -host diseaseT cell depletionCD34+ cell selectionGraft- versus -host disease-free and relapse-free survival (GRFS)The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/249795https://dx.doi.org/urn:doi:10.2991/chi.d.190613.001reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 FIS16/01433open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2497952026-06-06T12:50:31Z
dc.title.none.fl_str_mv Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
title Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
spellingShingle Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
Roldan, Elisa
Allogeneic transplant
Graft- versus -host disease
T cell depletion
CD34+ cell selection
Graft- versus -host disease-free and relapse-free survival (GRFS)
title_short Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
title_full Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
title_fullStr Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
title_full_unstemmed Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
title_sort Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
dc.creator.none.fl_str_mv Roldan, Elisa
Perales, Miguel Angel
Barba, Pere|||0000-0001-7076-7969
author Roldan, Elisa
author_facet Roldan, Elisa
Perales, Miguel Angel
Barba, Pere|||0000-0001-7076-7969
author_role author
author2 Perales, Miguel Angel
Barba, Pere|||0000-0001-7076-7969
author2_role author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Allogeneic transplant
Graft- versus -host disease
T cell depletion
CD34+ cell selection
Graft- versus -host disease-free and relapse-free survival (GRFS)
topic Allogeneic transplant
Graft- versus -host disease
T cell depletion
CD34+ cell selection
Graft- versus -host disease-free and relapse-free survival (GRFS)
description The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/249795
https://dx.doi.org/urn:doi:10.2991/chi.d.190613.001
url https://ddd.uab.cat/record/249795
https://dx.doi.org/urn:doi:10.2991/chi.d.190613.001
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FIS16/01433
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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