Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promisi...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:249795 |
| Acceso en línea: | https://ddd.uab.cat/record/249795 https://dx.doi.org/urn:doi:10.2991/chi.d.190613.001 |
| Access Level: | acceso abierto |
| Palabra clave: | Allogeneic transplant Graft- versus -host disease T cell depletion CD34+ cell selection Graft- versus -host disease-free and relapse-free survival (GRFS) |
| Sumario: | The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft- versus -host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice. |
|---|