Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions

Conclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tes...

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Detalles Bibliográficos
Autores: San Román, Jesus, Carricondo Orejana, Francisco Javier, Iglesias Moreno, María Cruz, Martín-Villares, Cristina, Poch Broto, Joaquín, Gil Loyzaga, Pablo
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/93504
Acceso en línea:https://hdl.handle.net/20.500.14352/93504
Access Level:acceso abierto
Palabra clave:616.21
Hypoacusia
excitotoxic amino acids
rat
kainic acid
cochlear decompression
cochlear evoked potentials
compound action potential of the auditory nerve
electrocochleography
artificial perilymph
Neurociencias (Biológicas)
Fisiología
Otorrinolaringología
2411.13 Fisiología de la Audición
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oai_identifier_str oai:docta.ucm.es:20.500.14352/93504
network_acronym_str ES
network_name_str España
repository_id_str
spelling Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusionsSan Román, JesusCarricondo Orejana, Francisco JavierIglesias Moreno, María CruzMartín-Villares, CristinaPoch Broto, JoaquínGil Loyzaga, Pablo616.21Hypoacusiaexcitotoxic amino acidsratkainic acidcochlear decompressioncochlear evoked potentialscompound action potential of the auditory nerveelectrocochleographyartificial perilymphNeurociencias (Biológicas)FisiologíaOtorrinolaringología2411.13 Fisiología de la AudiciónConclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tested. Objectives: The study focused on the accurate description of the electrophysiological effects on the cochlear potential recordings of perilymphatic perfusions. Methods: Two successive cochlear perilymphatic perfusions were carried out. The first used artificial perilymph. The second used artificial perilymph alone or a kainic acid (KA) solution in artificial perilymph. The compound action potential of the auditory nerve (CAP-AN) was recorded: (1) before the first perfusion, (2) after the first perfusion and (3) after the second perfusion, and compared between groups. Results: The first intracochlear perfusion with artificial perilymph produced significant effects in the CAP-AN that could be related to the surgical procedure. These effects were analysed separately from the effects produced by the KA. In particular, the KA administered intracochlearly produced a significant increase in the latency and a decrease in the amplitude of the CAP-AN N1 wave compared with the controls that were perfused twice with artificial perilymph.Taylor & FrancisUniversidad Complutense de Madrid20122012-09-0120122012-09-01journal articlehttp://purl.org/coar/resource_type/c_6501CVoRhttp://purl.org/coar/version/c_e19f295774971610info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/93504reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/935042026-06-02T12:44:21Z
dc.title.none.fl_str_mv Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
title Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
spellingShingle Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
San Román, Jesus
616.21
Hypoacusia
excitotoxic amino acids
rat
kainic acid
cochlear decompression
cochlear evoked potentials
compound action potential of the auditory nerve
electrocochleography
artificial perilymph
Neurociencias (Biológicas)
Fisiología
Otorrinolaringología
2411.13 Fisiología de la Audición
title_short Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
title_full Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
title_fullStr Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
title_full_unstemmed Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
title_sort Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
dc.creator.none.fl_str_mv San Román, Jesus
Carricondo Orejana, Francisco Javier
Iglesias Moreno, María Cruz
Martín-Villares, Cristina
Poch Broto, Joaquín
Gil Loyzaga, Pablo
author San Román, Jesus
author_facet San Román, Jesus
Carricondo Orejana, Francisco Javier
Iglesias Moreno, María Cruz
Martín-Villares, Cristina
Poch Broto, Joaquín
Gil Loyzaga, Pablo
author_role author
author2 Carricondo Orejana, Francisco Javier
Iglesias Moreno, María Cruz
Martín-Villares, Cristina
Poch Broto, Joaquín
Gil Loyzaga, Pablo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.21
Hypoacusia
excitotoxic amino acids
rat
kainic acid
cochlear decompression
cochlear evoked potentials
compound action potential of the auditory nerve
electrocochleography
artificial perilymph
Neurociencias (Biológicas)
Fisiología
Otorrinolaringología
2411.13 Fisiología de la Audición
topic 616.21
Hypoacusia
excitotoxic amino acids
rat
kainic acid
cochlear decompression
cochlear evoked potentials
compound action potential of the auditory nerve
electrocochleography
artificial perilymph
Neurociencias (Biológicas)
Fisiología
Otorrinolaringología
2411.13 Fisiología de la Audición
description Conclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tested. Objectives: The study focused on the accurate description of the electrophysiological effects on the cochlear potential recordings of perilymphatic perfusions. Methods: Two successive cochlear perilymphatic perfusions were carried out. The first used artificial perilymph. The second used artificial perilymph alone or a kainic acid (KA) solution in artificial perilymph. The compound action potential of the auditory nerve (CAP-AN) was recorded: (1) before the first perfusion, (2) after the first perfusion and (3) after the second perfusion, and compared between groups. Results: The first intracochlear perfusion with artificial perilymph produced significant effects in the CAP-AN that could be related to the surgical procedure. These effects were analysed separately from the effects produced by the KA. In particular, the KA administered intracochlearly produced a significant increase in the latency and a decrease in the amplitude of the CAP-AN N1 wave compared with the controls that were perfused twice with artificial perilymph.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-09-01
2012
2012-09-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
CVoR
http://purl.org/coar/version/c_e19f295774971610
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/93504
url https://hdl.handle.net/20.500.14352/93504
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419007899074560
score 15,301603

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