JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-or...

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Detalles Bibliográficos
Autores: Recasens Álvarez, Carles, Ferreira, Ana, Milán, Marco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/105644
Acceso en línea:https://hdl.handle.net/2445/105644
http://dx.doi.org/10.1038/ncomms13815
Access Level:acceso abierto
Palabra clave:Morfogènesi
Drosòfila
Morphogenesis
Drosophila
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spelling JAK/STAT controls organ size and fate specification by regulating morphogen production and signallingRecasens Álvarez, CarlesFerreira, AnaMilán, MarcoMorfogènesiDrosòfilaMorphogenesisDrosophilaA stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.Macmillan2017201720172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/105644http://dx.doi.org/10.1038/ncomms13815Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1038/ncomms13815Nature Communications, 2017, vol. 8, p. 13815cc by (c) Recasens et al., 2017http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1056442026-05-29T05:05:01Z
dc.title.none.fl_str_mv JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
title JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
spellingShingle JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
Recasens Álvarez, Carles
Morfogènesi
Drosòfila
Morphogenesis
Drosophila
title_short JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
title_full JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
title_fullStr JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
title_full_unstemmed JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
title_sort JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
dc.creator.none.fl_str_mv Recasens Álvarez, Carles
Ferreira, Ana
Milán, Marco
author Recasens Álvarez, Carles
author_facet Recasens Álvarez, Carles
Ferreira, Ana
Milán, Marco
author_role author
author2 Ferreira, Ana
Milán, Marco
author2_role author
author
dc.subject.none.fl_str_mv Morfogènesi
Drosòfila
Morphogenesis
Drosophila
topic Morfogènesi
Drosòfila
Morphogenesis
Drosophila
description A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/105644
http://dx.doi.org/10.1038/ncomms13815
url https://hdl.handle.net/2445/105644
http://dx.doi.org/10.1038/ncomms13815
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms13815
Nature Communications, 2017, vol. 8, p. 13815
dc.rights.none.fl_str_mv cc by (c) Recasens et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Recasens et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Macmillan
publisher.none.fl_str_mv Macmillan
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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