Potential mechanisms for cell-based gene therapy to treat HIV/AIDS
[Introduction] An estimated 35 million people are infected with HIV worldwide. Anti-retroviral therapy (ART) has reduced the morbidity and mortality of HIV-infected patients but efficacy requires strict adherence and the treatment is not curative. Most importantly, the emergence of drug-resistant vi...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión enviada para evaluación y publicación |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/415474 |
| Acceso en línea: | http://hdl.handle.net/10261/415474 https://api.elsevier.com/content/abstract/scopus_id/84921294877 |
| Access Level: | acceso abierto |
| Palabra clave: | HIV-1 RNA decoy RNA interference Antisense Antiviral Gene therapy Hematopoietic stem cell Intracellular immunization Nuclease Ribozyme Trans-dominant negative mutant |
| Sumario: | [Introduction] An estimated 35 million people are infected with HIV worldwide. Anti-retroviral therapy (ART) has reduced the morbidity and mortality of HIV-infected patients but efficacy requires strict adherence and the treatment is not curative. Most importantly, the emergence of drug-resistant virus strains and drug toxicity can restrict the long-term therapeutic efficacy in some patients. Therefore, novel treatment strategies that permanently control or eliminate the virus and restore the damaged immune system are required. Gene therapy against HIV infection has been the topic of intense investigations for the last two decades because it can theoretically provide such a durable anti-HIV control. |
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