Action of surfactants on the mammal epidermal skin barrier

BACKGROUND: Daily skin washing routines can promote undesirable effects on skin barrier function. The stratum corneum (SC) lipid matrix is crucial for skin barrier function. Skin cleansing products are mostly composed of surfactants: surface-active molecules that interact with skin lipids in several...

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Autores: Barba, Clara, Semenzato, Alessandra, Baratto, Gianni, Coderch Negra, M. Luisa
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/201208
Acceso en línea:http://hdl.handle.net/10261/201208
Access Level:acceso abierto
Palabra clave:Skin
Cornea
SC lipid
Surfactants
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spelling Action of surfactants on the mammal epidermal skin barrierBarba, ClaraSemenzato, AlessandraBaratto, GianniCoderch Negra, M. LuisaSkinCorneaSC lipidSurfactantsBACKGROUND: Daily skin washing routines can promote undesirable effects on skin barrier function. The stratum corneum (SC) lipid matrix is crucial for skin barrier function. Skin cleansing products are mostly composed of surfactants: surface-active molecules that interact with skin lipids in several ways. The main aim of this work was to investigate the effect produced by surfactants on skin barrier permeability. Porcine skin is a well-accepted and readily available model of the human skin barrier. The effect of two cleansing formulations (based on different surfactant mixtures) on the barrier properties of mammalian skin were evaluated. METHODS: Water sorption/desorption (DVS) experiments were used to measure skin permeability. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and confocal Raman were useful to study SC lipid organization. RESULTS: The results showed that while anionic surfactants (SLS) had a negative impact on the skin barrier, with a clear increase of alkyl chain disorder; cosurfactants present in the shampoo formulation diminished the detrimental effect of their primary ionic surfactant, inducing less modification on lipid intramolecular chain disorder. CONCLUSIONS: The obtained results confirmed that the mild cleansing formulations studied had gentle interaction with skin. The capacity to discriminate between detergent systems was clearly established with both DVS and spectroscopy techniques.The authors wish to thank the Spanish National Projects (Ministerio de Educación y Ciencia) CTQ2013-44998-P and 2014 SGR 1325 (AGAUR) for financial support. The authors are grateful to Montserrat Rigol Muxart and Núria Solanes Batlló from the Department of Cardiology (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Hospital Clínic, Universitat de Barcelona, Spain) for supplying porcine skin biopsies and J. Carilla for their expert assistance with the techniques used in this work.Peer reviewedMinerva MedicaMinisterio de Educación y Ciencia (España)Barba, Clara [0000-0002-3084-2925]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/201208reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-44998-P10.23736/S0392-0488.18.05874-1Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2012082026-05-22T06:33:51Z
dc.title.none.fl_str_mv Action of surfactants on the mammal epidermal skin barrier
title Action of surfactants on the mammal epidermal skin barrier
spellingShingle Action of surfactants on the mammal epidermal skin barrier
Barba, Clara
Skin
Cornea
SC lipid
Surfactants
title_short Action of surfactants on the mammal epidermal skin barrier
title_full Action of surfactants on the mammal epidermal skin barrier
title_fullStr Action of surfactants on the mammal epidermal skin barrier
title_full_unstemmed Action of surfactants on the mammal epidermal skin barrier
title_sort Action of surfactants on the mammal epidermal skin barrier
dc.creator.none.fl_str_mv Barba, Clara
Semenzato, Alessandra
Baratto, Gianni
Coderch Negra, M. Luisa
author Barba, Clara
author_facet Barba, Clara
Semenzato, Alessandra
Baratto, Gianni
Coderch Negra, M. Luisa
author_role author
author2 Semenzato, Alessandra
Baratto, Gianni
Coderch Negra, M. Luisa
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Educación y Ciencia (España)
Barba, Clara [0000-0002-3084-2925]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Skin
Cornea
SC lipid
Surfactants
topic Skin
Cornea
SC lipid
Surfactants
description BACKGROUND: Daily skin washing routines can promote undesirable effects on skin barrier function. The stratum corneum (SC) lipid matrix is crucial for skin barrier function. Skin cleansing products are mostly composed of surfactants: surface-active molecules that interact with skin lipids in several ways. The main aim of this work was to investigate the effect produced by surfactants on skin barrier permeability. Porcine skin is a well-accepted and readily available model of the human skin barrier. The effect of two cleansing formulations (based on different surfactant mixtures) on the barrier properties of mammalian skin were evaluated. METHODS: Water sorption/desorption (DVS) experiments were used to measure skin permeability. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and confocal Raman were useful to study SC lipid organization. RESULTS: The results showed that while anionic surfactants (SLS) had a negative impact on the skin barrier, with a clear increase of alkyl chain disorder; cosurfactants present in the shampoo formulation diminished the detrimental effect of their primary ionic surfactant, inducing less modification on lipid intramolecular chain disorder. CONCLUSIONS: The obtained results confirmed that the mild cleansing formulations studied had gentle interaction with skin. The capacity to discriminate between detergent systems was clearly established with both DVS and spectroscopy techniques.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/201208
url http://hdl.handle.net/10261/201208
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-44998-P
10.23736/S0392-0488.18.05874-1
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Minerva Medica
publisher.none.fl_str_mv Minerva Medica
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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