Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults
Background: Some amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of 9 amino acids, including branched-chain and aromatic amino acids, and multimorbidity. Methods: This res...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositório: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.uam.es:10486/715712 |
| Acesso em linha: | http://hdl.handle.net/10486/715712 https://dx.doi.org/10.1093/gerona/glac144 |
| Access Level: | Acceso aberto |
| Palavra-chave: | amino acids multimorbidity older adults physical functioning Medicina |
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Prospective Association Between Plasma Amino Acids and Multimorbidity in Older AdultsCaballero Díaz, Francisco FélixLana, AlbertoStruijk, Ellen A.Arias Fernández, LucíaYévenes Briones, Humberto AlejandroCárdenas Valladolid, JuanSalinero Fort, Miguel ÁngelBanegas Banegas, José RamónRodríguez Artalejo, FernandoLópez García, Estheramino acidsmultimorbidityolder adultsphysical functioningMedicinaBackground: Some amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of 9 amino acids, including branched-chain and aromatic amino acids, and multimorbidity. Methods: This research uses longitudinal data from the Seniors-ENRICA 2 study, a population-based cohort from Spain that comprises noninstitutionalized adults older than 65. Blood samples were extracted at baseline and after a follow-up period of 2 years for a total of 1 488 subjects. Participants’ information was linked with electronic health records. Chronic diseases were grouped into a list of 60 mutually exclusive conditions. A quantitative measure of multimorbidity, weighting morbidities by their regression coefficients on physical functioning, was employed and ranged from 0 to 100. Generalized estimating equation models were used to explore the relationship between plasma amino acids and multimorbidity, adjusting for sociodemographics, socioeconomic status, and lifestyle behaviors. Results: The mean age of participants at baseline was 73.6 (SD = 4.2) years, 49.6% were women. Higher concentrations of glutamine (coef. per mmol/l [95% confidence interval] = 10.1 [3.7, 16.6]), isoleucine (50.3 [21.7, 78.9]), and valine (15.5 [3.1, 28.0]) were significantly associated with higher multimorbidity scores, after adjusting for potential confounders. Body mass index could have influenced the relationship between isoleucine and multimorbidity (p = .016). Conclusions: Amino acids could play a role in regulating aging-related diseases. Glutamine and branched-chain amino acids as isoleucine and valine are prospectively associated and could serve as risk markers for multimorbidity in older adultsThis study has been funded by Instituto de Salud Carlos III through the FIS projects 19/319, 19/665 and 20/01040 (Instituto de Salud Carlos III, State Secretary of R+D+I) and cofunded by a European Regional Development Fund, “A way of shaping Europe.”Oxford University PressDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaFacultad de Medicina20232023-04-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/715712https://dx.doi.org/10.1093/gerona/glac144reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7157122026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults |
| title |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults |
| spellingShingle |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults Caballero Díaz, Francisco Félix amino acids multimorbidity older adults physical functioning Medicina |
| title_short |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults |
| title_full |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults |
| title_fullStr |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults |
| title_full_unstemmed |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults |
| title_sort |
Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults |
| dc.creator.none.fl_str_mv |
Caballero Díaz, Francisco Félix Lana, Alberto Struijk, Ellen A. Arias Fernández, Lucía Yévenes Briones, Humberto Alejandro Cárdenas Valladolid, Juan Salinero Fort, Miguel Ángel Banegas Banegas, José Ramón Rodríguez Artalejo, Fernando López García, Esther |
| author |
Caballero Díaz, Francisco Félix |
| author_facet |
Caballero Díaz, Francisco Félix Lana, Alberto Struijk, Ellen A. Arias Fernández, Lucía Yévenes Briones, Humberto Alejandro Cárdenas Valladolid, Juan Salinero Fort, Miguel Ángel Banegas Banegas, José Ramón Rodríguez Artalejo, Fernando López García, Esther |
| author_role |
author |
| author2 |
Lana, Alberto Struijk, Ellen A. Arias Fernández, Lucía Yévenes Briones, Humberto Alejandro Cárdenas Valladolid, Juan Salinero Fort, Miguel Ángel Banegas Banegas, José Ramón Rodríguez Artalejo, Fernando López García, Esther |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Preventiva y Salud Pública y Microbiología Facultad de Medicina |
| dc.subject.none.fl_str_mv |
amino acids multimorbidity older adults physical functioning Medicina |
| topic |
amino acids multimorbidity older adults physical functioning Medicina |
| description |
Background: Some amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of 9 amino acids, including branched-chain and aromatic amino acids, and multimorbidity. Methods: This research uses longitudinal data from the Seniors-ENRICA 2 study, a population-based cohort from Spain that comprises noninstitutionalized adults older than 65. Blood samples were extracted at baseline and after a follow-up period of 2 years for a total of 1 488 subjects. Participants’ information was linked with electronic health records. Chronic diseases were grouped into a list of 60 mutually exclusive conditions. A quantitative measure of multimorbidity, weighting morbidities by their regression coefficients on physical functioning, was employed and ranged from 0 to 100. Generalized estimating equation models were used to explore the relationship between plasma amino acids and multimorbidity, adjusting for sociodemographics, socioeconomic status, and lifestyle behaviors. Results: The mean age of participants at baseline was 73.6 (SD = 4.2) years, 49.6% were women. Higher concentrations of glutamine (coef. per mmol/l [95% confidence interval] = 10.1 [3.7, 16.6]), isoleucine (50.3 [21.7, 78.9]), and valine (15.5 [3.1, 28.0]) were significantly associated with higher multimorbidity scores, after adjusting for potential confounders. Body mass index could have influenced the relationship between isoleucine and multimorbidity (p = .016). Conclusions: Amino acids could play a role in regulating aging-related diseases. Glutamine and branched-chain amino acids as isoleucine and valine are prospectively associated and could serve as risk markers for multimorbidity in older adults |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-04-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/715712 https://dx.doi.org/10.1093/gerona/glac144 |
| url |
http://hdl.handle.net/10486/715712 https://dx.doi.org/10.1093/gerona/glac144 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Oxford University Press |
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Oxford University Press |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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