Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Nicolas, A; Sherva, R; Grenier-Boley, B; Kim, Y; Kikuchi, M; Timsina, J; de Rojas, I; Dalmasso, MC; Zhou, XP; Le Guen, Y; Arboleda-Bustos, CE; Bicalho, MAC; Guerchet, M; van der Lee, S; Goss, M; Castillo, A; Bellenguez, C; Küçükali, F; Satizabal, CL; Fongang, B; Yang, Q; Peters, O; Schneider, A; Dichgans, M; Rujescu, D; Scherbaum, N; Deckert, J; Riedel-Heller, S; Hausner, L; Molina-Porcel, L; Duezel, E; Grimmer, T; Wiltfang, J; Heilmann-Heimbach, S; Moebus, S; Tegos, T; Scarmeas, N; Dols-Icardo, O; Moreno, F; Pérez-Tur, J; Bullido, MJ; Pastor, P; Sánchez-Valle, R; Alvarez, V; Cao, H; Ip, NY; Fu, AKY; Ip, FCF; Olivar, N; Muchnik, C; Cuesta, C; Campanelli, L; Solis, P; Politis, DG; Kochen, S; Brusco, LI; Boada, M; García-González, P; Puerta, R; Mir, P; Real, LM; Pinol-Ripoll, G; García-Alberca, JM; Royo, JL; Rodriguez-Rodriguez, E; Soininen, H; Heikkinen, S; de Mendonça, A; Mehrabian, S; Traykov, L; Hort, J; Vyhnalek, M; Rasmussen, KL; Thomassen, JQ; Pijnenburg, YAL; Holstege, H; van Swieten, JC; Seelaar, H; Claassen, JAHR; Jansen, WJ; Ramakers, I; Verhey, F; van der Lugt, A; Scheltens, P; Ortega-Rojas, J; Mera, AGC; Mahecha, MF; Pardo, R; Arboleda, G; Bahrami, S; Fominykh, V; Selbaek, G; Graff, C; Papenberg, G; Giedraitis, V; Boland, A; Deleuze, JF; de Marco, LA; de Moraes, EN; Viana, BD; Cintra, MTG; Juarez-Cedillo, T; Griswold, AJ; Forund, T; Haines, J; Farrer, L; Destefano, A; Wijsman, E; Mayeux, R; Pericak-Vance, M; Kunkle, B; Goate, A; Schellenberg, GD; Vardarajan, B; Wang, LS; Leung, YY; Dalgard, CL; Nicolas, G; Wallon, D; Dufouil, C; Pasquier, F; Hanon, O; Debette, S; Gruenblatt, E; Popp, J; Angel, B; Gloger, S; Chacon, MV; Aranguiz, R; Orellana, P; Slachevsky, A; Gonzalez-Billault, C; Albala, C; Fuentes, P; Sachdev, P; Mather, KA; Hauger, RL; Merritt, V; Panizzon, M; Zhang, R; Gaziano, JM; Ghidoni, R; Galimberti, D; Arosio, B; Mecocci, P; Solfrizzi, V; Parnetti, L; Squassina, A; Tremolizzo, L; Borroni, B; Nacmias, B; Caffarra, P; Seripa, D; Rainero, I; Daniele, A; Piras, F; Leonard, HL; Yokoyama, JS; Nalls, MA; Miyashita, A; Hara, N; Ozaki, K; Niida, S; Williams, J; Masullo, C; Amouyel, P; Preux, PM; Mbelesso, P; Bandzouzi, B; Saykin, A; Jessen, F; Kehoe, PG; Van Duijn, C; Ben Salem, N; Frikke-Schmidt, R; Cherni, L; Greicius, MD; Tsolaki, M; Sánchez-Juan, P; Silva, MAR; Porter, T; Laws, SM; Sleegers, K; Ingelsson, M; Dartigues, JF; Seshadri, S; Rossi, G; Morelli, L; Hiltunen, M; Sims, R; van der Flier, W; Andreassen, OA; Arboleda, H; Cruchaga, C; Escott-Price, V; Ruiz, A; Lee, KH; Ikeuchi, T; Ramirez, A; Gim, J; Logue, M; Lambert, JC

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospina...

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Autores:	Nicolas, A, Sherva, R, Grenier-Boley, B, Kim, Y, Kikuchi, M, Timsina, J, de Rojas, I, Dalmasso, MC, Zhou, XP, Le Guen, Y, Arboleda-Bustos, CE, Bicalho, MAC, Guerchet, M, van der Lee, S, Goss, M, Castillo, A, Bellenguez, C, Küçükali, F, Satizabal, CL, Fongang, B, Yang, Q, Peters, O, Schneider, A, Dichgans, M, Rujescu, D, Scherbaum, N, Deckert, J, Riedel-Heller, S, Hausner, L, Molina-Porcel, L, Duezel, E, Grimmer, T, Wiltfang, J, Heilmann-Heimbach, S, Moebus, S, Tegos, T, Scarmeas, N, Dols-Icardo, O, Moreno, F, Pérez-Tur, J, Bullido, MJ, Pastor, P, Sánchez-Valle, R, Alvarez, V, Cao, H, Ip, NY, Fu, AKY, Ip, FCF, Olivar, N, Muchnik, C, Cuesta, C, Campanelli, L, Solis, P, Politis, DG, Kochen, S, Brusco, LI, Boada, M, García-González, P, Puerta, R, Mir, P, Real, LM, Pinol-Ripoll, G, García-Alberca, JM, Royo, JL, Rodriguez-Rodriguez, E, Soininen, H, Heikkinen, S, de Mendonça, A, Mehrabian, S, Traykov, L, Hort, J, Vyhnalek, M, Rasmussen, KL, Thomassen, JQ, Pijnenburg, YAL, Holstege, H, van Swieten, JC, Seelaar, H, Claassen, JAHR, Jansen, WJ, Ramakers, I, Verhey, F, van der Lugt, A, Scheltens, P, Ortega-Rojas, J, Mera, AGC, Mahecha, MF, Pardo, R, Arboleda, G, Bahrami, S, Fominykh, V, Selbaek, G, Graff, C, Papenberg, G, Giedraitis, V, Boland, A, Deleuze, JF, de Marco, LA, de Moraes, EN, Viana, BD, Cintra, MTG, Juarez-Cedillo, T, Griswold, AJ, Forund, T, Haines, J, Farrer, L, Destefano, A, Wijsman, E, Mayeux, R, Pericak-Vance, M, Kunkle, B, Goate, A, Schellenberg, GD, Vardarajan, B, Wang, LS, Leung, YY, Dalgard, CL, Nicolas, G, Wallon, D, Dufouil, C, Pasquier, F, Hanon, O, Debette, S, Gruenblatt, E, Popp, J, Angel, B, Gloger, S, Chacon, MV, Aranguiz, R, Orellana, P, Slachevsky, A, Gonzalez-Billault, C, Albala, C, Fuentes, P, Sachdev, P, Mather, KA, Hauger, RL, Merritt, V, Panizzon, M, Zhang, R, Gaziano, JM, Ghidoni, R, Galimberti, D, Arosio, B, Mecocci, P, Solfrizzi, V, Parnetti, L, Squassina, A, Tremolizzo, L, Borroni, B, Nacmias, B, Caffarra, P, Seripa, D, Rainero, I, Daniele, A, Piras, F, Leonard, HL, Yokoyama, JS, Nalls, MA, Miyashita, A, Hara, N, Ozaki, K, Niida, S, Williams, J, Masullo, C, Amouyel, P, Preux, PM, Mbelesso, P, Bandzouzi, B, Saykin, A, Jessen, F, Kehoe, PG, Van Duijn, C, Ben Salem, N, Frikke-Schmidt, R, Cherni, L, Greicius, MD, Tsolaki, M, Sánchez-Juan, P, Silva, MAR, Porter, T, Laws, SM, Sleegers, K, Ingelsson, M, Dartigues, JF, Seshadri, S, Rossi, G, Morelli, L, Hiltunen, M, Sims, R, van der Flier, W, Andreassen, OA, Arboleda, H, Cruchaga, C, Escott-Price, V, Ruiz, A, Lee, KH, Ikeuchi, T, Ramirez, A, Gim, J, Logue, M, Lambert, JC
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2025
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p19963
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19963
Access Level:	acceso abierto

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spelling	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populationsNicolas, ASherva, RGrenier-Boley, BKim, YKikuchi, MTimsina, Jde Rojas, IDalmasso, MCZhou, XPLe Guen, YArboleda-Bustos, CEBicalho, MACGuerchet, Mvan der Lee, SGoss, MCastillo, ABellenguez, CKüçükali, FSatizabal, CLFongang, BYang, QPeters, OSchneider, ADichgans, MRujescu, DScherbaum, NDeckert, JRiedel-Heller, SHausner, LMolina-Porcel, LDuezel, EGrimmer, TWiltfang, JHeilmann-Heimbach, SMoebus, STegos, TScarmeas, NDols-Icardo, OMoreno, FPérez-Tur, JBullido, MJPastor, PSánchez-Valle, RAlvarez, VCao, HIp, NYFu, AKYIp, FCFOlivar, NMuchnik, CCuesta, CCampanelli, LSolis, PPolitis, DGKochen, SBrusco, LIBoada, MGarcía-González, PPuerta, RMir, PReal, LMPinol-Ripoll, GGarcía-Alberca, JMRoyo, JLRodriguez-Rodriguez, ESoininen, HHeikkinen, Sde Mendonça, AMehrabian, STraykov, LHort, JVyhnalek, MRasmussen, KLThomassen, JQPijnenburg, YALHolstege, Hvan Swieten, JCSeelaar, HClaassen, JAHRJansen, WJRamakers, IVerhey, Fvan der Lugt, AScheltens, POrtega-Rojas, JMera, AGCMahecha, MFPardo, RArboleda, GBahrami, SFominykh, VSelbaek, GGraff, CPapenberg, GGiedraitis, VBoland, ADeleuze, JFde Marco, LAde Moraes, ENViana, BDCintra, MTGJuarez-Cedillo, TGriswold, AJForund, THaines, JFarrer, LDestefano, AWijsman, EMayeux, RPericak-Vance, MKunkle, BGoate, ASchellenberg, GDVardarajan, BWang, LSLeung, YYDalgard, CLNicolas, GWallon, DDufouil, CPasquier, FHanon, ODebette, SGruenblatt, EPopp, JAngel, BGloger, SChacon, MVAranguiz, ROrellana, PSlachevsky, AGonzalez-Billault, CAlbala, CFuentes, PSachdev, PMather, KAHauger, RLMerritt, VPanizzon, MZhang, RGaziano, JMGhidoni, RGalimberti, DArosio, BMecocci, PSolfrizzi, VParnetti, LSquassina, ATremolizzo, LBorroni, BNacmias, BCaffarra, PSeripa, DRainero, IDaniele, APiras, FLeonard, HLYokoyama, JSNalls, MAMiyashita, AHara, NOzaki, KNiida, SWilliams, JMasullo, CAmouyel, PPreux, PMMbelesso, PBandzouzi, BSaykin, AJessen, FKehoe, PGVan Duijn, CBen Salem, NFrikke-Schmidt, RCherni, LGreicius, MDTsolaki, MSánchez-Juan, PSilva, MARPorter, TLaws, SMSleegers, KIngelsson, MDartigues, JFSeshadri, SRossi, GMorelli, LHiltunen, MSims, Rvan der Flier, WAndreassen, OAArboleda, HCruchaga, CEscott-Price, VRuiz, ALee, KHIkeuchi, TRamirez, AGim, JLogue, MLambert, JCA polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.NATURE PUBLISHING GROUP2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19963NATURE GENETICSISSN: 10614036ISSNe: 15461718reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p199632026-06-14T12:41:47Z
dc.title.none.fl_str_mv	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
title	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
spellingShingle	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations Nicolas, A
title_short	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
title_full	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
title_fullStr	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
title_full_unstemmed	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
title_sort	Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
dc.creator.none.fl_str_mv	Nicolas, A Sherva, R Grenier-Boley, B Kim, Y Kikuchi, M Timsina, J de Rojas, I Dalmasso, MC Zhou, XP Le Guen, Y Arboleda-Bustos, CE Bicalho, MAC Guerchet, M van der Lee, S Goss, M Castillo, A Bellenguez, C Küçükali, F Satizabal, CL Fongang, B Yang, Q Peters, O Schneider, A Dichgans, M Rujescu, D Scherbaum, N Deckert, J Riedel-Heller, S Hausner, L Molina-Porcel, L Duezel, E Grimmer, T Wiltfang, J Heilmann-Heimbach, S Moebus, S Tegos, T Scarmeas, N Dols-Icardo, O Moreno, F Pérez-Tur, J Bullido, MJ Pastor, P Sánchez-Valle, R Alvarez, V Cao, H Ip, NY Fu, AKY Ip, FCF Olivar, N Muchnik, C Cuesta, C Campanelli, L Solis, P Politis, DG Kochen, S Brusco, LI Boada, M García-González, P Puerta, R Mir, P Real, LM Pinol-Ripoll, G García-Alberca, JM Royo, JL Rodriguez-Rodriguez, E Soininen, H Heikkinen, S de Mendonça, A Mehrabian, S Traykov, L Hort, J Vyhnalek, M Rasmussen, KL Thomassen, JQ Pijnenburg, YAL Holstege, H van Swieten, JC Seelaar, H Claassen, JAHR Jansen, WJ Ramakers, I Verhey, F van der Lugt, A Scheltens, P Ortega-Rojas, J Mera, AGC Mahecha, MF Pardo, R Arboleda, G Bahrami, S Fominykh, V Selbaek, G Graff, C Papenberg, G Giedraitis, V Boland, A Deleuze, JF de Marco, LA de Moraes, EN Viana, BD Cintra, MTG Juarez-Cedillo, T Griswold, AJ Forund, T Haines, J Farrer, L Destefano, A Wijsman, E Mayeux, R Pericak-Vance, M Kunkle, B Goate, A Schellenberg, GD Vardarajan, B Wang, LS Leung, YY Dalgard, CL Nicolas, G Wallon, D Dufouil, C Pasquier, F Hanon, O Debette, S Gruenblatt, E Popp, J Angel, B Gloger, S Chacon, MV Aranguiz, R Orellana, P Slachevsky, A Gonzalez-Billault, C Albala, C Fuentes, P Sachdev, P Mather, KA Hauger, RL Merritt, V Panizzon, M Zhang, R Gaziano, JM Ghidoni, R Galimberti, D Arosio, B Mecocci, P Solfrizzi, V Parnetti, L Squassina, A Tremolizzo, L Borroni, B Nacmias, B Caffarra, P Seripa, D Rainero, I Daniele, A Piras, F Leonard, HL Yokoyama, JS Nalls, MA Miyashita, A Hara, N Ozaki, K Niida, S Williams, J Masullo, C Amouyel, P Preux, PM Mbelesso, P Bandzouzi, B Saykin, A Jessen, F Kehoe, PG Van Duijn, C Ben Salem, N Frikke-Schmidt, R Cherni, L Greicius, MD Tsolaki, M Sánchez-Juan, P Silva, MAR Porter, T Laws, SM Sleegers, K Ingelsson, M Dartigues, JF Seshadri, S Rossi, G Morelli, L Hiltunen, M Sims, R van der Flier, W Andreassen, OA Arboleda, H Cruchaga, C Escott-Price, V Ruiz, A Lee, KH Ikeuchi, T Ramirez, A Gim, J Logue, M Lambert, JC
author	Nicolas, A
author_facet	Nicolas, A Sherva, R Grenier-Boley, B Kim, Y Kikuchi, M Timsina, J de Rojas, I Dalmasso, MC Zhou, XP Le Guen, Y Arboleda-Bustos, CE Bicalho, MAC Guerchet, M van der Lee, S Goss, M Castillo, A Bellenguez, C Küçükali, F Satizabal, CL Fongang, B Yang, Q Peters, O Schneider, A Dichgans, M Rujescu, D Scherbaum, N Deckert, J Riedel-Heller, S Hausner, L Molina-Porcel, L Duezel, E Grimmer, T Wiltfang, J Heilmann-Heimbach, S Moebus, S Tegos, T Scarmeas, N Dols-Icardo, O Moreno, F Pérez-Tur, J Bullido, MJ Pastor, P Sánchez-Valle, R Alvarez, V Cao, H Ip, NY Fu, AKY Ip, FCF Olivar, N Muchnik, C Cuesta, C Campanelli, L Solis, P Politis, DG Kochen, S Brusco, LI Boada, M García-González, P Puerta, R Mir, P Real, LM Pinol-Ripoll, G García-Alberca, JM Royo, JL Rodriguez-Rodriguez, E Soininen, H Heikkinen, S de Mendonça, A Mehrabian, S Traykov, L Hort, J Vyhnalek, M Rasmussen, KL Thomassen, JQ Pijnenburg, YAL Holstege, H van Swieten, JC Seelaar, H Claassen, JAHR Jansen, WJ Ramakers, I Verhey, F van der Lugt, A Scheltens, P Ortega-Rojas, J Mera, AGC Mahecha, MF Pardo, R Arboleda, G Bahrami, S Fominykh, V Selbaek, G Graff, C Papenberg, G Giedraitis, V Boland, A Deleuze, JF de Marco, LA de Moraes, EN Viana, BD Cintra, MTG Juarez-Cedillo, T Griswold, AJ Forund, T Haines, J Farrer, L Destefano, A Wijsman, E Mayeux, R Pericak-Vance, M Kunkle, B Goate, A Schellenberg, GD Vardarajan, B Wang, LS Leung, YY Dalgard, CL Nicolas, G Wallon, D Dufouil, C Pasquier, F Hanon, O Debette, S Gruenblatt, E Popp, J Angel, B Gloger, S Chacon, MV Aranguiz, R Orellana, P Slachevsky, A Gonzalez-Billault, C Albala, C Fuentes, P Sachdev, P Mather, KA Hauger, RL Merritt, V Panizzon, M Zhang, R Gaziano, JM Ghidoni, R Galimberti, D Arosio, B Mecocci, P Solfrizzi, V Parnetti, L Squassina, A Tremolizzo, L Borroni, B Nacmias, B Caffarra, P Seripa, D Rainero, I Daniele, A Piras, F Leonard, HL Yokoyama, JS Nalls, MA Miyashita, A Hara, N Ozaki, K Niida, S Williams, J Masullo, C Amouyel, P Preux, PM Mbelesso, P Bandzouzi, B Saykin, A Jessen, F Kehoe, PG Van Duijn, C Ben Salem, N Frikke-Schmidt, R Cherni, L Greicius, MD Tsolaki, M Sánchez-Juan, P Silva, MAR Porter, T Laws, SM Sleegers, K Ingelsson, M Dartigues, JF Seshadri, S Rossi, G Morelli, L Hiltunen, M Sims, R van der Flier, W Andreassen, OA Arboleda, H Cruchaga, C Escott-Price, V Ruiz, A Lee, KH Ikeuchi, T Ramirez, A Gim, J Logue, M Lambert, JC
author_role	author
author2	Sherva, R Grenier-Boley, B Kim, Y Kikuchi, M Timsina, J de Rojas, I Dalmasso, MC Zhou, XP Le Guen, Y Arboleda-Bustos, CE Bicalho, MAC Guerchet, M van der Lee, S Goss, M Castillo, A Bellenguez, C Küçükali, F Satizabal, CL Fongang, B Yang, Q Peters, O Schneider, A Dichgans, M Rujescu, D Scherbaum, N Deckert, J Riedel-Heller, S Hausner, L Molina-Porcel, L Duezel, E Grimmer, T Wiltfang, J Heilmann-Heimbach, S Moebus, S Tegos, T Scarmeas, N Dols-Icardo, O Moreno, F Pérez-Tur, J Bullido, MJ Pastor, P Sánchez-Valle, R Alvarez, V Cao, H Ip, NY Fu, AKY Ip, FCF Olivar, N Muchnik, C Cuesta, C Campanelli, L Solis, P Politis, DG Kochen, S Brusco, LI Boada, M García-González, P Puerta, R Mir, P Real, LM Pinol-Ripoll, G García-Alberca, JM Royo, JL Rodriguez-Rodriguez, E Soininen, H Heikkinen, S de Mendonça, A Mehrabian, S Traykov, L Hort, J Vyhnalek, M Rasmussen, KL Thomassen, JQ Pijnenburg, YAL Holstege, H van Swieten, JC Seelaar, H Claassen, JAHR Jansen, WJ Ramakers, I Verhey, F van der Lugt, A Scheltens, P Ortega-Rojas, J Mera, AGC Mahecha, MF Pardo, R Arboleda, G Bahrami, S Fominykh, V Selbaek, G Graff, C Papenberg, G Giedraitis, V Boland, A Deleuze, JF de Marco, LA de Moraes, EN Viana, BD Cintra, MTG Juarez-Cedillo, T Griswold, AJ Forund, T Haines, J Farrer, L Destefano, A Wijsman, E Mayeux, R Pericak-Vance, M Kunkle, B Goate, A Schellenberg, GD Vardarajan, B Wang, LS Leung, YY Dalgard, CL Nicolas, G Wallon, D Dufouil, C Pasquier, F Hanon, O Debette, S Gruenblatt, E Popp, J Angel, B Gloger, S Chacon, MV Aranguiz, R Orellana, P Slachevsky, A Gonzalez-Billault, C Albala, C Fuentes, P Sachdev, P Mather, KA Hauger, RL Merritt, V Panizzon, M Zhang, R Gaziano, JM Ghidoni, R Galimberti, D Arosio, B Mecocci, P Solfrizzi, V Parnetti, L Squassina, A Tremolizzo, L Borroni, B Nacmias, B Caffarra, P Seripa, D Rainero, I Daniele, A Piras, F Leonard, HL Yokoyama, JS Nalls, MA Miyashita, A Hara, N Ozaki, K Niida, S Williams, J Masullo, C Amouyel, P Preux, PM Mbelesso, P Bandzouzi, B Saykin, A Jessen, F Kehoe, PG Van Duijn, C Ben Salem, N Frikke-Schmidt, R Cherni, L Greicius, MD Tsolaki, M Sánchez-Juan, P Silva, MAR Porter, T Laws, SM Sleegers, K Ingelsson, M Dartigues, JF Seshadri, S Rossi, G Morelli, L Hiltunen, M Sims, R van der Flier, W Andreassen, OA Arboleda, H Cruchaga, C Escott-Price, V Ruiz, A Lee, KH Ikeuchi, T Ramirez, A Gim, J Logue, M Lambert, JC
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
description	A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.
publishDate	2025
dc.date.none.fl_str_mv	2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19963
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19963
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	NATURE PUBLISHING GROUP
publisher.none.fl_str_mv	NATURE PUBLISHING GROUP
dc.source.none.fl_str_mv	NATURE GENETICS ISSN: 10614036 ISSNe: 15461718 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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score	15.812455

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

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