Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospina...

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Detalles Bibliográficos
Autores: Nicolas, Aude, Sherva, Richard, Grenier-Boley, Bejamin, Dimi, Yoontae, Kikuchi, Masataka, Timsina, Jigyasha, Rojas, Itziar de, Dalmasso, María Carolina, Zhou, Xiaopu, Le Guen, Yann, Arboleda-Bustos, Carlos E., Aparecida, María, Bicalho, Camargos, Guerchet, Maëlenn, Van der Lee, Sven, Goss, Mónica, Castillo, Atahualpa, Bellenguez, Céline, Rodríguez Rodríguez, Eloy Manuel
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/37429
Acceso en línea:https://hdl.handle.net/10902/37429
Access Level:acceso abierto
Descripción
Sumario:A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.

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