Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and infl...

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Autores: Abiega Etxabe, Oihane, Beccari Galeano, Marlene Soledad, Diaz-Aparicio, Irune, Nadjar, Agnes, Layé, Sophie, Leyrolle, Quentin, Gómez Nicola, Diego, Domercq García, María, Pérez-Samartín, Alberto, Sánchez-Zafra, Víctor, Paris Guerrero, Ignacio, Valero Gómez-Lobo, Jorge, Savage, Julie C., Hui, Chin-Wai, Tremblay, Marie-Ève, Deudero, Juan J. P., Brewster, Amy L., Anderson, Anne E., Zaldumbide Dueñas, Laura, Galbarriatu, Lara, Marinas, Ainhoa, Vivanco Ruiz, María del Mar, Matute Almau, Carlos José, Maletic Savatic, Mirjana, Encinas Pérez, Juan Manuel, Sierra Saavedra, Amanda
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/19619
Acceso en línea:http://hdl.handle.net/10810/19619
Access Level:acceso abierto
Palabra clave:medicine
neuroscience
neurobiology
AGRICULTURAL AND BIOLOGICAL SCIENCES
BIOCHEMISTRY AND MOLECULAR BIOLOGY
IMMUNOLOGY AND MICROBIOLOGY
NEUROSCIENCES
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis UncouplingAbiega Etxabe, OihaneBeccari Galeano, Marlene SoledadDiaz-Aparicio, IruneNadjar, AgnesLayé, SophieLeyrolle, QuentinGómez Nicola, DiegoDomercq García, MaríaPérez-Samartín, AlbertoSánchez-Zafra, VíctorParis Guerrero, IgnacioValero Gómez-Lobo, JorgeSavage, Julie C.Hui, Chin-WaiTremblay, Marie-ÈveDeudero, Juan J. P.Brewster, Amy L.Anderson, Anne E.Zaldumbide Dueñas, LauraGalbarriatu, LaraMarinas, AinhoaVivanco Ruiz, María del MarMatute Almau, Carlos JoséMaletic Savatic, MirjanaEncinas Pérez, Juan ManuelSierra Saavedra, AmandamedicineneuroscienceneurobiologyAGRICULTURAL AND BIOLOGICAL SCIENCESBIOCHEMISTRY AND MOLECULAR BIOLOGYIMMUNOLOGY AND MICROBIOLOGYNEUROSCIENCESPhagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and inflammation.201620162016info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/19619reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttp://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002466info:eu-repo/semantics/openAccessoai:addi.ehu.eus:10810/196192026-06-18T09:23:17Z
dc.title.none.fl_str_mv Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
title Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
spellingShingle Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Abiega Etxabe, Oihane
medicine
neuroscience
neurobiology
AGRICULTURAL AND BIOLOGICAL SCIENCES
BIOCHEMISTRY AND MOLECULAR BIOLOGY
IMMUNOLOGY AND MICROBIOLOGY
NEUROSCIENCES
title_short Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
title_full Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
title_fullStr Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
title_full_unstemmed Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
title_sort Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
dc.creator.none.fl_str_mv Abiega Etxabe, Oihane
Beccari Galeano, Marlene Soledad
Diaz-Aparicio, Irune
Nadjar, Agnes
Layé, Sophie
Leyrolle, Quentin
Gómez Nicola, Diego
Domercq García, María
Pérez-Samartín, Alberto
Sánchez-Zafra, Víctor
Paris Guerrero, Ignacio
Valero Gómez-Lobo, Jorge
Savage, Julie C.
Hui, Chin-Wai
Tremblay, Marie-Ève
Deudero, Juan J. P.
Brewster, Amy L.
Anderson, Anne E.
Zaldumbide Dueñas, Laura
Galbarriatu, Lara
Marinas, Ainhoa
Vivanco Ruiz, María del Mar
Matute Almau, Carlos José
Maletic Savatic, Mirjana
Encinas Pérez, Juan Manuel
Sierra Saavedra, Amanda
author Abiega Etxabe, Oihane
author_facet Abiega Etxabe, Oihane
Beccari Galeano, Marlene Soledad
Diaz-Aparicio, Irune
Nadjar, Agnes
Layé, Sophie
Leyrolle, Quentin
Gómez Nicola, Diego
Domercq García, María
Pérez-Samartín, Alberto
Sánchez-Zafra, Víctor
Paris Guerrero, Ignacio
Valero Gómez-Lobo, Jorge
Savage, Julie C.
Hui, Chin-Wai
Tremblay, Marie-Ève
Deudero, Juan J. P.
Brewster, Amy L.
Anderson, Anne E.
Zaldumbide Dueñas, Laura
Galbarriatu, Lara
Marinas, Ainhoa
Vivanco Ruiz, María del Mar
Matute Almau, Carlos José
Maletic Savatic, Mirjana
Encinas Pérez, Juan Manuel
Sierra Saavedra, Amanda
author_role author
author2 Beccari Galeano, Marlene Soledad
Diaz-Aparicio, Irune
Nadjar, Agnes
Layé, Sophie
Leyrolle, Quentin
Gómez Nicola, Diego
Domercq García, María
Pérez-Samartín, Alberto
Sánchez-Zafra, Víctor
Paris Guerrero, Ignacio
Valero Gómez-Lobo, Jorge
Savage, Julie C.
Hui, Chin-Wai
Tremblay, Marie-Ève
Deudero, Juan J. P.
Brewster, Amy L.
Anderson, Anne E.
Zaldumbide Dueñas, Laura
Galbarriatu, Lara
Marinas, Ainhoa
Vivanco Ruiz, María del Mar
Matute Almau, Carlos José
Maletic Savatic, Mirjana
Encinas Pérez, Juan Manuel
Sierra Saavedra, Amanda
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv medicine
neuroscience
neurobiology
AGRICULTURAL AND BIOLOGICAL SCIENCES
BIOCHEMISTRY AND MOLECULAR BIOLOGY
IMMUNOLOGY AND MICROBIOLOGY
NEUROSCIENCES
topic medicine
neuroscience
neurobiology
AGRICULTURAL AND BIOLOGICAL SCIENCES
BIOCHEMISTRY AND MOLECULAR BIOLOGY
IMMUNOLOGY AND MICROBIOLOGY
NEUROSCIENCES
description Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and inflammation.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/19619
url http://hdl.handle.net/10810/19619
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002466
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418865969070080
score 15.301603

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