Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and infl...

Descripción completa

Detalles Bibliográficos
Autores: Abiega Etxabe, Oihane, Beccari Galeano, Marlene Soledad, Diaz-Aparicio, Irune, Nadjar, Agnes, Layé, Sophie, Leyrolle, Quentin, Gómez Nicola, Diego, Domercq García, María, Pérez-Samartín, Alberto, Sánchez-Zafra, Víctor, Paris Guerrero, Ignacio, Valero Gómez-Lobo, Jorge, Savage, Julie C., Hui, Chin-Wai, Tremblay, Marie-Ève, Deudero, Juan J. P., Brewster, Amy L., Anderson, Anne E., Zaldumbide Dueñas, Laura, Galbarriatu, Lara, Marinas, Ainhoa, Vivanco Ruiz, María del Mar, Matute Almau, Carlos José, Maletic Savatic, Mirjana, Encinas Pérez, Juan Manuel, Sierra Saavedra, Amanda
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/19619
Acceso en línea:http://hdl.handle.net/10810/19619
Access Level:acceso abierto
Palabra clave:medicine
neuroscience
neurobiology
AGRICULTURAL AND BIOLOGICAL SCIENCES
BIOCHEMISTRY AND MOLECULAR BIOLOGY
IMMUNOLOGY AND MICROBIOLOGY
NEUROSCIENCES
Descripción
Sumario:Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and inflammation.

Similares en LA Referencia