Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients
Neural basis of language switching and the cognitive models of bilingualism remain controversial. We explored the functional neuroanatomy of language switching implementing a new multimodal protocol assessing neuropsychological, functional magnetic resonance and intraoperative electrical stimulation...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/218069 |
| Acceso en línea: | https://hdl.handle.net/2445/218069 |
| Access Level: | acceso abierto |
| Palabra clave: | Estimulació elèctrica Tumors cerebrals Mapatge del cervell Lòbul frontal Electric stimulation Brain tumors Brain mapping Frontal lobe |
| id |
ES_c3f9f73feacb2208e78f9f596ff5f2f8 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:2445/218069 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patientsSierpowska, JoannaFernandez-Coello, AlejandroGómez Andrés, AlbaCamins, ÀngelsCastañer, SaraJuncadella i Puig, MontserratGabarrós, AndreuRodríguez Fornells, AntoniEstimulació elèctricaTumors cerebralsMapatge del cervellLòbul frontalElectric stimulationBrain tumorsBrain mappingFrontal lobeNeural basis of language switching and the cognitive models of bilingualism remain controversial. We explored the functional neuroanatomy of language switching implementing a new multimodal protocol assessing neuropsychological, functional magnetic resonance and intraoperative electrical stimulation mapping results.A prospective series of 9 Spanish-Catalan bilingual candidates for awake brain surgery underwent a specific language switching paradigm implemented both before and after surgery, throughout the electrical stimulation procedure and during functional magnetic resonance both pre- and postoperatively. All patients were harboring left-hemispheric intrinsic brain lesions and were presenting functional language-related activations within the affected hemisphere.Language functional maps were reconstructed on the basis of the intraoperative electrical stimulation results and compared to the functional magnetic resonance findings. Single language-naming sites (Spanish and Catalan), as well as language switching naming sites were detected by electrical stimulation mapping in 8 patients (in one patient only Spanish related sites were detected). Single naming points outnumbered the switching points and did not overlap with each other. Within the frontal lobe, the single language naming sites were found significantly more frequently within the inferior frontal gyrus as compared to the middle frontal gyrus [X-2 (1) = 20.3, p < .001]. Contrarily, switching naming sites were distributed across the middle frontal gyrus significantly more often than within the inferior frontal gyrus [X-2 (1) = 4.1, p = .043]. Notably, there was not always an overlap between functional magnetic resonance and electrical stimulation mapping findings. After surgery, patients did not report involuntary language switching and their neuropsychological scores did not differ significantly from the pre-surgical examinations. Our results suggest a functional division of the frontal cortex between naming and language switching functions, supporting that non-language specific cognitive control prefrontal regions (middle frontal gyrus) are essential to maintain an effective communication together with the classical language-related sites (inferior frontal gyms).Elsevier Masson SAS2025202520182025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion35 p.application/pdfhttps://hdl.handle.net/2445/218069Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.cortex.2017.10.017Cortex, 2018, vol. 99, p. 78-92https://doi.org/10.1016/j.cortex.2017.10.017(c) Elsevier Masson SAS, 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2180692026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients |
| title |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients |
| spellingShingle |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients Sierpowska, Joanna Estimulació elèctrica Tumors cerebrals Mapatge del cervell Lòbul frontal Electric stimulation Brain tumors Brain mapping Frontal lobe |
| title_short |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients |
| title_full |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients |
| title_fullStr |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients |
| title_full_unstemmed |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients |
| title_sort |
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients |
| dc.creator.none.fl_str_mv |
Sierpowska, Joanna Fernandez-Coello, Alejandro Gómez Andrés, Alba Camins, Àngels Castañer, Sara Juncadella i Puig, Montserrat Gabarrós, Andreu Rodríguez Fornells, Antoni |
| author |
Sierpowska, Joanna |
| author_facet |
Sierpowska, Joanna Fernandez-Coello, Alejandro Gómez Andrés, Alba Camins, Àngels Castañer, Sara Juncadella i Puig, Montserrat Gabarrós, Andreu Rodríguez Fornells, Antoni |
| author_role |
author |
| author2 |
Fernandez-Coello, Alejandro Gómez Andrés, Alba Camins, Àngels Castañer, Sara Juncadella i Puig, Montserrat Gabarrós, Andreu Rodríguez Fornells, Antoni |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Estimulació elèctrica Tumors cerebrals Mapatge del cervell Lòbul frontal Electric stimulation Brain tumors Brain mapping Frontal lobe |
| topic |
Estimulació elèctrica Tumors cerebrals Mapatge del cervell Lòbul frontal Electric stimulation Brain tumors Brain mapping Frontal lobe |
| description |
Neural basis of language switching and the cognitive models of bilingualism remain controversial. We explored the functional neuroanatomy of language switching implementing a new multimodal protocol assessing neuropsychological, functional magnetic resonance and intraoperative electrical stimulation mapping results.A prospective series of 9 Spanish-Catalan bilingual candidates for awake brain surgery underwent a specific language switching paradigm implemented both before and after surgery, throughout the electrical stimulation procedure and during functional magnetic resonance both pre- and postoperatively. All patients were harboring left-hemispheric intrinsic brain lesions and were presenting functional language-related activations within the affected hemisphere.Language functional maps were reconstructed on the basis of the intraoperative electrical stimulation results and compared to the functional magnetic resonance findings. Single language-naming sites (Spanish and Catalan), as well as language switching naming sites were detected by electrical stimulation mapping in 8 patients (in one patient only Spanish related sites were detected). Single naming points outnumbered the switching points and did not overlap with each other. Within the frontal lobe, the single language naming sites were found significantly more frequently within the inferior frontal gyrus as compared to the middle frontal gyrus [X-2 (1) = 20.3, p < .001]. Contrarily, switching naming sites were distributed across the middle frontal gyrus significantly more often than within the inferior frontal gyrus [X-2 (1) = 4.1, p = .043]. Notably, there was not always an overlap between functional magnetic resonance and electrical stimulation mapping findings. After surgery, patients did not report involuntary language switching and their neuropsychological scores did not differ significantly from the pre-surgical examinations. Our results suggest a functional division of the frontal cortex between naming and language switching functions, supporting that non-language specific cognitive control prefrontal regions (middle frontal gyrus) are essential to maintain an effective communication together with the classical language-related sites (inferior frontal gyms). |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/218069 |
| url |
https://hdl.handle.net/2445/218069 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1016/j.cortex.2017.10.017 Cortex, 2018, vol. 99, p. 78-92 https://doi.org/10.1016/j.cortex.2017.10.017 |
| dc.rights.none.fl_str_mv |
(c) Elsevier Masson SAS, 2018 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Elsevier Masson SAS, 2018 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
35 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier Masson SAS |
| publisher.none.fl_str_mv |
Elsevier Masson SAS |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869418841791004672 |
| score |
15.812429 |