Cortical thinning over two years after first-episode psychosis depends on age of onset

First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP pa...

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Detalles Bibliográficos
Autores: Pina Camacho, Laura, Martinez, Kenia, Díaz Caneja, Covadonga M., Mezquida Mateos, Gisela, Cuesta, Manuel J., Moreno, Carmen (Moreno Koch), Amoretti Guadall, Silvia, González-Pinto, Ana, Arango, Celso, Vieta i Pascual, Eduard, 1963-, Castro Fornieles, Josefina, Lobo, Antonio, Fraguas, David, Bernardo Arroyo, Miquel, Janssen, Joost, Parellada, Mara, PEPs Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/193844
Acceso en línea:https://hdl.handle.net/2445/193844
Access Level:acceso abierto
Palabra clave:Psicosi
Cervell
Escorça cerebral
Lòbul frontal
Lòbul temporal
Edat
Psychoses
Brain
Cerebral cortex
Frontal lobe
Temporal lobe
Age
Descripción
Sumario:First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15-35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe.

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