Multicenter, Prospective, Case-Control Study of Exposome in Melanoma

UV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate the association between melanoma and exposome factors in the Spanish population with a prospective multicenter case-control study....

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Detalles Bibliográficos
Autores: Navarro-Bielsa, A, Gracia-Cazaña, T, Almagro, M, De-la-Fuente-Meira, S, Florez, A, Yélamos, O, Montero-Vilchez, T, González-Cruz, C, Diago, A, Abadías-Granado, I, Fuentelsaz, V, Colmenero, M, Bañuls, J, Arias-Santiago, S, Buendía-Eisman, A, Almenara-Blasco, M, Gil-Pallares, P, Gilaberte, Y
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:dnet:isabial_____::a9bd6ddf85b8d1420c845483cf2223de
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones12613
https://www.sciencedirect.com/science/article/pii/S0001731025001395?pes=vor&utm_source=clarivate&getft_integrator=clarivate
Access Level:acceso abierto
Palabra clave:Exposome
Melanoma
Diet
Environmental exposure
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spelling Multicenter, Prospective, Case-Control Study of Exposome in MelanomaNavarro-Bielsa, AGracia-Cazaña, TAlmagro, MDe-la-Fuente-Meira, SFlorez, AYélamos, OMontero-Vilchez, TGonzález-Cruz, CDiago, AAbadías-Granado, IFuentelsaz, VColmenero, MBañuls, JArias-Santiago, SBuendía-Eisman, AAlmenara-Blasco, MGil-Pallares, PGilaberte, YExposomeMelanomaDietEnvironmental exposureUV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate the association between melanoma and exposome factors in the Spanish population with a prospective multicenter case-control study. Case group included patients with melanoma while the control group included people who attended the consultations as companions without a past medical history of skin cancer. A total of 73 melanoma patients and 126 controls were included. The former group included more outdoor workers, a history of skin cancer, drug use (acetylsalicylic acid, antidepressants and ACE inhibitors, p < 0.05), more sun exposure (p < 0.001) and more sunburns(p = 0.04). Controls used shade (p = 0.04) or clothing (p < 0.001) and the sun protection factor (SPF) used 15 years earlier was higher (p = 0.04). Melanoma-related exposome factors are associated with sun exposure, drug intake and food. Prevention strategies should target specific populations, such as outdoor workers by promoting sun-safe behaviors and healthy lifestyle habits since childhood.ELSEVIER ESPANA2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones12613https://www.sciencedirect.com/science/article/pii/S0001731025001395?pes=vor&utm_source=clarivate&getft_integrator=clarivateActas Dermo-SifiliograficasISSN: 00017310ISSNe: 15782190reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Españolinfo:eu-repo/semantics/openAccessoai:dnet:isabial_____::a9bd6ddf85b8d1420c845483cf2223de2026-06-12T10:20:37Z
dc.title.none.fl_str_mv Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
title Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
spellingShingle Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
Navarro-Bielsa, A
Exposome
Melanoma
Diet
Environmental exposure
title_short Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
title_full Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
title_fullStr Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
title_full_unstemmed Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
title_sort Multicenter, Prospective, Case-Control Study of Exposome in Melanoma
dc.creator.none.fl_str_mv Navarro-Bielsa, A
Gracia-Cazaña, T
Almagro, M
De-la-Fuente-Meira, S
Florez, A
Yélamos, O
Montero-Vilchez, T
González-Cruz, C
Diago, A
Abadías-Granado, I
Fuentelsaz, V
Colmenero, M
Bañuls, J
Arias-Santiago, S
Buendía-Eisman, A
Almenara-Blasco, M
Gil-Pallares, P
Gilaberte, Y
author Navarro-Bielsa, A
author_facet Navarro-Bielsa, A
Gracia-Cazaña, T
Almagro, M
De-la-Fuente-Meira, S
Florez, A
Yélamos, O
Montero-Vilchez, T
González-Cruz, C
Diago, A
Abadías-Granado, I
Fuentelsaz, V
Colmenero, M
Bañuls, J
Arias-Santiago, S
Buendía-Eisman, A
Almenara-Blasco, M
Gil-Pallares, P
Gilaberte, Y
author_role author
author2 Gracia-Cazaña, T
Almagro, M
De-la-Fuente-Meira, S
Florez, A
Yélamos, O
Montero-Vilchez, T
González-Cruz, C
Diago, A
Abadías-Granado, I
Fuentelsaz, V
Colmenero, M
Bañuls, J
Arias-Santiago, S
Buendía-Eisman, A
Almenara-Blasco, M
Gil-Pallares, P
Gilaberte, Y
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Exposome
Melanoma
Diet
Environmental exposure
topic Exposome
Melanoma
Diet
Environmental exposure
description UV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate the association between melanoma and exposome factors in the Spanish population with a prospective multicenter case-control study. Case group included patients with melanoma while the control group included people who attended the consultations as companions without a past medical history of skin cancer. A total of 73 melanoma patients and 126 controls were included. The former group included more outdoor workers, a history of skin cancer, drug use (acetylsalicylic acid, antidepressants and ACE inhibitors, p < 0.05), more sun exposure (p < 0.001) and more sunburns(p = 0.04). Controls used shade (p = 0.04) or clothing (p < 0.001) and the sun protection factor (SPF) used 15 years earlier was higher (p = 0.04). Melanoma-related exposome factors are associated with sun exposure, drug intake and food. Prevention strategies should target specific populations, such as outdoor workers by promoting sun-safe behaviors and healthy lifestyle habits since childhood.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones12613
https://www.sciencedirect.com/science/article/pii/S0001731025001395?pes=vor&utm_source=clarivate&getft_integrator=clarivate
url https://isabial.portalinvestigacion.com/publicaciones12613
https://www.sciencedirect.com/science/article/pii/S0001731025001395?pes=vor&utm_source=clarivate&getft_integrator=clarivate
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER ESPANA
publisher.none.fl_str_mv ELSEVIER ESPANA
dc.source.none.fl_str_mv Actas Dermo-Sifiliograficas
ISSN: 00017310
ISSNe: 15782190
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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