Estudio prospectivo multicéntrico de casos y controles del exposoma en melanoma

UV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate the association between melanoma and exposome factors in the Spanish population with a prospective multicenter case-control study....

Descripción completa

Detalles Bibliográficos
Autores: Navarro-Bielsa, Alba|||0000-0003-1171-6007, Gracia-Cazaña, T., Almagro, M., De-la-Fuente-Meira, S., Flórez, None, Yélamos, Oriol|||0000-0002-8058-3095, Montero-Vilchez, Trinidad|||0000-0003-4035-7955, González-Cruz, C.|||0000-0003-0117-8858, Diago, A., Abadías-Granado, Isabel, Fuentelsaz, V., Colmenero, M., Bañuls, J., Arias-Santiago, Salvador|||0000-0002-4186-1435, Buendía-Eisman, A., Almenara-Blasco, Manuel|||0000-0002-4350-401X, Gil-Pallares, Pedro|||0000-0001-8469-1942, Gilaberte Calzada, Y.
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:español
OAI Identifier:oai:ddd.uab.cat:322739
Acceso en línea:https://ddd.uab.cat/record/322739
https://dx.doi.org/urn:doi:10.1016/j.ad.2024.09.022
Access Level:acceso abierto
Palabra clave:Diet
Dieta
Environmental exposure
Exposición ambiental
Exposoma
Exposome
Melanoma
Descripción
Sumario:UV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate the association between melanoma and exposome factors in the Spanish population with a prospective multicenter case-control study. Case group included patients with melanoma while the control group included people who attended the consultations as companions without a past medical history of skin cancer. A total of 73 melanoma patients and 126 controls were included. The former group included more outdoor workers, a history of skin cancer, drug use (acetylsalicylic acid, antidepressants and ACE inhibitors, p < 0.05), more sun exposure (p < 0.001) and more sunburns (p = 0.04). Controls used shade (p = 0.04) or clothing (p < 0.001) and the sun protection factor (SPF) used 15 years earlier was higher (p = 0.04). Melanoma-related exposome factors are associated with sun exposure, drug intake and food. Prevention strategies should target specific populations, such as outdoor workers by promoting sun-safe behaviors and healthy lifestyle habits since childhood.

Similares en LA Referencia