Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness

Cognitive impairment after critical illness is frequent but poorly understood and its trajec­ tory is difficult to predict. Alterations in Neurovascular Coupling (NVC), the interaction between neuronal activity and regional cerebral blood flow, might be used as a biomarker for cognitive function aft...

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Detalhes bibliográficos
Autor: Costafreda Martín, Adriana
Formato: tesis de maestría
Fecha de publicación:2024
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/424106
Acesso em linha:https://hdl.handle.net/2117/424106
Access Level:acceso abierto
Palavra-chave:Cognitive neuroscience
Electrophysiology
cognitive impairment
functional near­infrared spectroscopy
neurovascular coupling
encephalogra­phy
Neurociència cognitiva
Electrofisiologia
Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
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spelling Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illnessCostafreda Martín, AdrianaCognitive neuroscienceElectrophysiologycognitive impairmentfunctional near­infrared spectroscopyneurovascular couplingencephalogra­phyNeurociència cognitivaElectrofisiologiaÀrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdicaCognitive impairment after critical illness is frequent but poorly understood and its trajec­ tory is difficult to predict. Alterations in Neurovascular Coupling (NVC), the interaction between neuronal activity and regional cerebral blood flow, might be used as a biomarker for cognitive function after critical illness. This study used integrated Electroencephalog­ raphy (EEG) and Functional Near­Infrared Spectroscopy (fNIRS) to capture neural activity and hemodynamic responses during an n­back task paradigm. Theta power in the frontal midline and Oxygenated Hemoglobin (HbO) concentration in the frontal cortex were an­ alyzed in both healthy controls and critically ill patients across the n­back tasks. The analysis revealed higher Theta power in patients compared to controls, with a notable de­ crease during the 3­back task, indicating difficulties with higher task complexity. Healthy controls exhibited a greater increase in HbO concentration, suggesting better hemody­ namic response under cognitive load. Despite the lack of statistically significant results, the study provided insights into NVC and cognitive function in critically ill patients.Universitat Politècnica de CatalunyaBragós Bardia, RamonAndersen, Tobias Soren20242024-09-0920252025-02-13master thesishttp://purl.org/coar/resource_type/c_bdccNAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/2117/424106reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4241062026-05-27T15:37:01Z
dc.title.none.fl_str_mv Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
title Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
spellingShingle Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
Costafreda Martín, Adriana
Cognitive neuroscience
Electrophysiology
cognitive impairment
functional near­infrared spectroscopy
neurovascular coupling
encephalogra­phy
Neurociència cognitiva
Electrofisiologia
Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
title_short Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
title_full Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
title_fullStr Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
title_full_unstemmed Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
title_sort Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
dc.creator.none.fl_str_mv Costafreda Martín, Adriana
author Costafreda Martín, Adriana
author_facet Costafreda Martín, Adriana
author_role author
dc.contributor.none.fl_str_mv Bragós Bardia, Ramon
Andersen, Tobias Soren
dc.subject.none.fl_str_mv Cognitive neuroscience
Electrophysiology
cognitive impairment
functional near­infrared spectroscopy
neurovascular coupling
encephalogra­phy
Neurociència cognitiva
Electrofisiologia
Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
topic Cognitive neuroscience
Electrophysiology
cognitive impairment
functional near­infrared spectroscopy
neurovascular coupling
encephalogra­phy
Neurociència cognitiva
Electrofisiologia
Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
description Cognitive impairment after critical illness is frequent but poorly understood and its trajec­ tory is difficult to predict. Alterations in Neurovascular Coupling (NVC), the interaction between neuronal activity and regional cerebral blood flow, might be used as a biomarker for cognitive function after critical illness. This study used integrated Electroencephalog­ raphy (EEG) and Functional Near­Infrared Spectroscopy (fNIRS) to capture neural activity and hemodynamic responses during an n­back task paradigm. Theta power in the frontal midline and Oxygenated Hemoglobin (HbO) concentration in the frontal cortex were an­ alyzed in both healthy controls and critically ill patients across the n­back tasks. The analysis revealed higher Theta power in patients compared to controls, with a notable de­ crease during the 3­back task, indicating difficulties with higher task complexity. Healthy controls exhibited a greater increase in HbO concentration, suggesting better hemody­ namic response under cognitive load. Despite the lack of statistically significant results, the study provided insights into NVC and cognitive function in critically ill patients.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-09-09
2025
2025-02-13
dc.type.none.fl_str_mv master thesis
http://purl.org/coar/resource_type/c_bdcc
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/424106
url https://hdl.handle.net/2117/424106
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universitat Politècnica de Catalunya
publisher.none.fl_str_mv Universitat Politècnica de Catalunya
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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