Neurovascular coupling measured by fNIRS-EEG as a biomarker for predicting cognitive functioning after critical illness
Cognitive impairment after critical illness is frequent but poorly understood and its trajec tory is difficult to predict. Alterations in Neurovascular Coupling (NVC), the interaction between neuronal activity and regional cerebral blood flow, might be used as a biomarker for cognitive function aft...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/424106 |
| Acceso en línea: | https://hdl.handle.net/2117/424106 |
| Access Level: | acceso abierto |
| Palabra clave: | Cognitive neuroscience Electrophysiology cognitive impairment functional nearinfrared spectroscopy neurovascular coupling encephalography Neurociència cognitiva Electrofisiologia Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica |
| Sumario: | Cognitive impairment after critical illness is frequent but poorly understood and its trajec tory is difficult to predict. Alterations in Neurovascular Coupling (NVC), the interaction between neuronal activity and regional cerebral blood flow, might be used as a biomarker for cognitive function after critical illness. This study used integrated Electroencephalog raphy (EEG) and Functional NearInfrared Spectroscopy (fNIRS) to capture neural activity and hemodynamic responses during an nback task paradigm. Theta power in the frontal midline and Oxygenated Hemoglobin (HbO) concentration in the frontal cortex were an alyzed in both healthy controls and critically ill patients across the nback tasks. The analysis revealed higher Theta power in patients compared to controls, with a notable de crease during the 3back task, indicating difficulties with higher task complexity. Healthy controls exhibited a greater increase in HbO concentration, suggesting better hemody namic response under cognitive load. Despite the lack of statistically significant results, the study provided insights into NVC and cognitive function in critically ill patients. |
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