Functional and Cognitive Decline Is Associated With Increased Endothelial Cell Inflammation and Platelet Activation
Increased life expectancy is usually associated with comorbidities, such as cardio and cerebrovascular disease causing impaired functionality. A common underlying cause of these comorbidities is vascular inflammation and injury. Elevated levels of circulating microvesicles (cMV), as a product of a h...
| Authors: | , , , , , |
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| Format: | article |
| Publication Date: | 2021 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:269689 |
| Online Access: | https://ddd.uab.cat/record/269689 https://dx.doi.org/urn:doi:10.3389/fcell.2021.716435 |
| Access Level: | Open access |
| Keyword: | Circulating microvesicles Octogenarians Successful aging Cognitive decline Inflammation Platelet activation Thrombomodulin Endothelial cells |
| Summary: | Increased life expectancy is usually associated with comorbidities, such as cardio and cerebrovascular disease causing impaired functionality. A common underlying cause of these comorbidities is vascular inflammation and injury. Elevated levels of circulating microvesicles (cMV), as a product of a hemostatic and inflammatory cell activation, could be direct mapping of an imbalanced hemostasis. In this manuscript, we aimed to investigate by liquid biopsy whether successful aging can be discriminated by cMV levels and phenotype. To this purpose, we included 135 community-dwelling octogenarians in a cross-sectional study. Successful aging was defined as good functional (Barthel Index. |
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