The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).

Bacillus subtilis is a spore-forming microorganism, recognized as a safe probiotic strain. Its endospores are easily produced at a large scale, can be dehydrated and maintain their characteristics after long-term storage, providing great advantages for their application in aquafeeds. Nonetheless, kn...

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Autores: Vicente- Gil, Samuel, Nogales-Mérida, Silvia, Gonçalves, Gabriela, Serra, Claudia R, Ordás, M. Camino, Tafalla, Carolina, Díaz- Rosales, Patricia
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
OAI Identifier:oai:burjcdigital.urjc.es:10115/37970
Acceso en línea:https://hdl.handle.net/10115/37970
Access Level:acceso abierto
Palabra clave:Aquacultured fish
Probiotics
Sporeformes
Mucosal immunity
Enzymatic activities
Oxidative status
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spelling The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).Vicente- Gil, SamuelNogales-Mérida, SilviaGonçalves, GabrielaSerra, Claudia ROrdás, M. CaminoTafalla, CarolinaDíaz- Rosales, PatriciaAquacultured fishProbioticsSporeformesMucosal immunityEnzymatic activitiesOxidative statusBacillus subtilis is a spore-forming microorganism, recognized as a safe probiotic strain. Its endospores are easily produced at a large scale, can be dehydrated and maintain their characteristics after long-term storage, providing great advantages for their application in aquafeeds. Nonetheless, knowledge on the effects that B. subtilis provokes on fish mucosal immunity is still scarce. In this context, the aim of this work was to explore the effects of the oral administration of B. subtilis spores to rainbow trout (Oncorhynchus mykiss) for 30 days on the intestinal and skin mucus, focusing on a range of immune and enzymatic parameters. Thus, fish supplemented with B. subtilis spores showed increased levels of total immunoglobulin (Ig) in intestinal and skin mucus, as well as IgM levels in both mucus and serum. B. subtilis spores induced an increase of peroxidase activities in mucus from both sources. Although superoxide dismutase (SOD) activity was not affected by the spores, NO production significantly decreased in skin mucus. Finally, the bactericidal activity of the intestinal and skin mucus was significantly higher in fish fed the probiotic spores. The results obtained demonstrate that the dietary supplementation with B. subtilis spores enhances mucosal defense mechanisms by increasing immunological parameters of the intestinal and skin mucus.Elsevier202420242024info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10115/37970reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlosinstname:Universidad Rey Juan CarlosInglésAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:burjcdigital.urjc.es:10115/379702026-06-24T12:48:17Z
dc.title.none.fl_str_mv The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
title The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
spellingShingle The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
Vicente- Gil, Samuel
Aquacultured fish
Probiotics
Sporeformes
Mucosal immunity
Enzymatic activities
Oxidative status
title_short The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
title_full The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
title_fullStr The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
title_full_unstemmed The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
title_sort The oral delivery of Bacillus subtilis spores modulates skin and intestinal mucus responses in rainbow trout (Oncorhynchus mykiss).
dc.creator.none.fl_str_mv Vicente- Gil, Samuel
Nogales-Mérida, Silvia
Gonçalves, Gabriela
Serra, Claudia R
Ordás, M. Camino
Tafalla, Carolina
Díaz- Rosales, Patricia
author Vicente- Gil, Samuel
author_facet Vicente- Gil, Samuel
Nogales-Mérida, Silvia
Gonçalves, Gabriela
Serra, Claudia R
Ordás, M. Camino
Tafalla, Carolina
Díaz- Rosales, Patricia
author_role author
author2 Nogales-Mérida, Silvia
Gonçalves, Gabriela
Serra, Claudia R
Ordás, M. Camino
Tafalla, Carolina
Díaz- Rosales, Patricia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Aquacultured fish
Probiotics
Sporeformes
Mucosal immunity
Enzymatic activities
Oxidative status
topic Aquacultured fish
Probiotics
Sporeformes
Mucosal immunity
Enzymatic activities
Oxidative status
description Bacillus subtilis is a spore-forming microorganism, recognized as a safe probiotic strain. Its endospores are easily produced at a large scale, can be dehydrated and maintain their characteristics after long-term storage, providing great advantages for their application in aquafeeds. Nonetheless, knowledge on the effects that B. subtilis provokes on fish mucosal immunity is still scarce. In this context, the aim of this work was to explore the effects of the oral administration of B. subtilis spores to rainbow trout (Oncorhynchus mykiss) for 30 days on the intestinal and skin mucus, focusing on a range of immune and enzymatic parameters. Thus, fish supplemented with B. subtilis spores showed increased levels of total immunoglobulin (Ig) in intestinal and skin mucus, as well as IgM levels in both mucus and serum. B. subtilis spores induced an increase of peroxidase activities in mucus from both sources. Although superoxide dismutase (SOD) activity was not affected by the spores, NO production significantly decreased in skin mucus. Finally, the bactericidal activity of the intestinal and skin mucus was significantly higher in fish fed the probiotic spores. The results obtained demonstrate that the dietary supplementation with B. subtilis spores enhances mucosal defense mechanisms by increasing immunological parameters of the intestinal and skin mucus.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10115/37970
url https://hdl.handle.net/10115/37970
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial 4.0 International
https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
collection BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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