Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years

Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were inclu...

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Detalhes bibliográficos
Autores: Campos-Sánchez, I, Navarrete-Muñoz, EM, Martens, DS, Riaño-Galán, I, Lertxundi, A, Llop, S, Guxens, M, Rodríguez-Dehli, C, Lertxundi, N, Soler-Blasco, R, Vrijheid, M, Nawrot, TS, Wright, J, Yang, TC, Mceachan, R, Gützkow, KB, Chatzi, VL, Vafeiadi, M, Kampouri, M, Grazuleviciene, R, Andrusaityte, S, Lepeule, J, Valera-Gran, D
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p18362
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/18362
Access Level:acceso abierto
Palavra-chave:telomere length
attention deficit-hyperactivity disorder
neurodevelopment
children
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spelling Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 YearsCampos-Sánchez, INavarrete-Muñoz, EMMartens, DSRiaño-Galán, ILertxundi, ALlop, SGuxens, MRodríguez-Dehli, CLertxundi, NSoler-Blasco, RVrijheid, MNawrot, TSWright, JYang, TCMceachan, RGützkow, KBChatzi, VLVafeiadi, MKampouri, MGrazuleviciene, RAndrusaityte, SLepeule, JValera-Gran, Dtelomere lengthattention deficit-hyperactivity disorderneurodevelopmentchildrenObjective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners' Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations.Results: Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; p = .022).Conclusion: While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.SAGE PUBLICATIONS INC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/18362Journal of Attention DisordersISSN: 10870547ISSNe: 15571246reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p183622026-06-11T12:45:17Z
dc.title.none.fl_str_mv Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
title Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
spellingShingle Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
Campos-Sánchez, I
telomere length
attention deficit-hyperactivity disorder
neurodevelopment
children
title_short Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
title_full Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
title_fullStr Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
title_full_unstemmed Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
title_sort Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
dc.creator.none.fl_str_mv Campos-Sánchez, I
Navarrete-Muñoz, EM
Martens, DS
Riaño-Galán, I
Lertxundi, A
Llop, S
Guxens, M
Rodríguez-Dehli, C
Lertxundi, N
Soler-Blasco, R
Vrijheid, M
Nawrot, TS
Wright, J
Yang, TC
Mceachan, R
Gützkow, KB
Chatzi, VL
Vafeiadi, M
Kampouri, M
Grazuleviciene, R
Andrusaityte, S
Lepeule, J
Valera-Gran, D
author Campos-Sánchez, I
author_facet Campos-Sánchez, I
Navarrete-Muñoz, EM
Martens, DS
Riaño-Galán, I
Lertxundi, A
Llop, S
Guxens, M
Rodríguez-Dehli, C
Lertxundi, N
Soler-Blasco, R
Vrijheid, M
Nawrot, TS
Wright, J
Yang, TC
Mceachan, R
Gützkow, KB
Chatzi, VL
Vafeiadi, M
Kampouri, M
Grazuleviciene, R
Andrusaityte, S
Lepeule, J
Valera-Gran, D
author_role author
author2 Navarrete-Muñoz, EM
Martens, DS
Riaño-Galán, I
Lertxundi, A
Llop, S
Guxens, M
Rodríguez-Dehli, C
Lertxundi, N
Soler-Blasco, R
Vrijheid, M
Nawrot, TS
Wright, J
Yang, TC
Mceachan, R
Gützkow, KB
Chatzi, VL
Vafeiadi, M
Kampouri, M
Grazuleviciene, R
Andrusaityte, S
Lepeule, J
Valera-Gran, D
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv telomere length
attention deficit-hyperactivity disorder
neurodevelopment
children
topic telomere length
attention deficit-hyperactivity disorder
neurodevelopment
children
description Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners' Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations.Results: Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; p = .022).Conclusion: While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/18362
url https://fisabio.portalinvestigacion.com/publicaciones/18362
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS INC
publisher.none.fl_str_mv SAGE PUBLICATIONS INC
dc.source.none.fl_str_mv Journal of Attention Disorders
ISSN: 10870547
ISSNe: 15571246
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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