Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years

Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were inclu...

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Bibliographic Details
Authors: Campos-Sánchez, I, Navarrete-Muñoz, EM, Martens, DS, Riaño-Galán, I, Lertxundi, A, Llop, S, Guxens, M, Rodríguez-Dehli, C, Lertxundi, N, Soler-Blasco, R, Vrijheid, M, Nawrot, TS, Wright, J, Yang, TC, Mceachan, R, Gützkow, KB, Chatzi, VL, Vafeiadi, M, Kampouri, M, Grazuleviciene, R, Andrusaityte, S, Lepeule, J, Valera-Gran, D
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repository:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11139
Online Access:https://isabial.portalinvestigacion.com/publicaciones11139
https://doi.org/10.1177/10870547251314923
Access Level:Open access
Keyword:telomere length
attention deficit-hyperactivity disorder
neurodevelopment
children
Description
Summary:Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners' Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations.Results: Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; p = .022).Conclusion: While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.

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