A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation

Quantum dots are nanoparticles with very promising biomedical applications. However, before these applications can be authorized, a complete toxicological assessment of quantum dots toxicity is needed. This work studied the effects of cadmium-selenium quantum dots on the tran scriptome of T98G human...

Descripción completa

Detalles Bibliográficos
Autores: Fuster, Encarnación, Candela, Héctor, Estévez, Jorge, Vilanova, Eugenio, SOGORB, MIGUEL A
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/30581
Acceso en línea:https://hdl.handle.net/11000/30581
Access Level:acceso abierto
Palabra clave:quantum dots
nanoparticles
neuroinflammation
gonadotropin-releasing hormone receptor pathway
T98G glioblastoma
nanosafety
in vitro
Biología
CDU::5 - Ciencias puras y naturales::57 - Biología
id ES_c1b58911aaa772d2bdfeb43362f3aca8
oai_identifier_str oai:dspace.umh.es:11000/30581
network_acronym_str ES
network_name_str España
repository_id_str
spelling A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus RegulationFuster, EncarnaciónCandela, HéctorEstévez, JorgeVilanova, EugenioSOGORB, MIGUEL Aquantum dotsnanoparticlesneuroinflammationgonadotropin-releasing hormone receptor pathwayT98G glioblastomananosafetyin vitroBiologíaCDU::5 - Ciencias puras y naturales::57 - BiologíaQuantum dots are nanoparticles with very promising biomedical applications. However, before these applications can be authorized, a complete toxicological assessment of quantum dots toxicity is needed. This work studied the effects of cadmium-selenium quantum dots on the tran scriptome of T98G human glioblastoma cells. It was found that 72-h exposure to 40 µg/mL (a dose that reduces cell viability by less than 10%) alters the transcriptome of these cells in biological pro cesses and molecular pathways, which address mainly neuroinflammation and hormonal control of hypothalamus via the gonadotropin-releasing hormone receptor. The biological significance of neuroinflammation alterations is still to be determined because, unlike studies performed with other nanomaterials, the expression of the genes encoding pro-inflammatory interleukins is down-regulated rather than up-regulated. The hormonal control alterations of the hypothalamus pose a new concern about a potential adverse effect of quantum dots on fertility. In any case, more studies are needed to clarify the biological relevance of these findings, and especially to assess the real risk of toxicity derived from quantum dots exposure appearing in physiologically relevant scenarios.MDPIDepartamentos de la UMH::Biología Aplicada202420242022info:eu-repo/semantics/articleapplication/pdf17application/pdfhttps://hdl.handle.net/11000/30581reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés232267https://doi.org/10.3390/ijms23042267info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/305812026-05-27T13:36:21Z
dc.title.none.fl_str_mv A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
title A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
spellingShingle A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
Fuster, Encarnación
quantum dots
nanoparticles
neuroinflammation
gonadotropin-releasing hormone receptor pathway
T98G glioblastoma
nanosafety
in vitro
Biología
CDU::5 - Ciencias puras y naturales::57 - Biología
title_short A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
title_full A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
title_fullStr A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
title_full_unstemmed A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
title_sort A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation
dc.creator.none.fl_str_mv Fuster, Encarnación
Candela, Héctor
Estévez, Jorge
Vilanova, Eugenio
SOGORB, MIGUEL A
author Fuster, Encarnación
author_facet Fuster, Encarnación
Candela, Héctor
Estévez, Jorge
Vilanova, Eugenio
SOGORB, MIGUEL A
author_role author
author2 Candela, Héctor
Estévez, Jorge
Vilanova, Eugenio
SOGORB, MIGUEL A
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Biología Aplicada
dc.subject.none.fl_str_mv quantum dots
nanoparticles
neuroinflammation
gonadotropin-releasing hormone receptor pathway
T98G glioblastoma
nanosafety
in vitro
Biología
CDU::5 - Ciencias puras y naturales::57 - Biología
topic quantum dots
nanoparticles
neuroinflammation
gonadotropin-releasing hormone receptor pathway
T98G glioblastoma
nanosafety
in vitro
Biología
CDU::5 - Ciencias puras y naturales::57 - Biología
description Quantum dots are nanoparticles with very promising biomedical applications. However, before these applications can be authorized, a complete toxicological assessment of quantum dots toxicity is needed. This work studied the effects of cadmium-selenium quantum dots on the tran scriptome of T98G human glioblastoma cells. It was found that 72-h exposure to 40 µg/mL (a dose that reduces cell viability by less than 10%) alters the transcriptome of these cells in biological pro cesses and molecular pathways, which address mainly neuroinflammation and hormonal control of hypothalamus via the gonadotropin-releasing hormone receptor. The biological significance of neuroinflammation alterations is still to be determined because, unlike studies performed with other nanomaterials, the expression of the genes encoding pro-inflammatory interleukins is down-regulated rather than up-regulated. The hormonal control alterations of the hypothalamus pose a new concern about a potential adverse effect of quantum dots on fertility. In any case, more studies are needed to clarify the biological relevance of these findings, and especially to assess the real risk of toxicity derived from quantum dots exposure appearing in physiologically relevant scenarios.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/30581
url https://hdl.handle.net/11000/30581
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 23
2267
https://doi.org/10.3390/ijms23042267
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
17
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418582378545152
score 15,300719

Similares en LA Referencia