The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models

Hemolymph coagulation is among the major arms of the humoral immune response in crustaceans. According to the current model, hemolymph clotting in decapod crustacean relies mostly on the polymerization of the plasmatic clotting protein (CP) which is directly promoted by calcium-depended transglutami...

Descripción completa

Detalles Bibliográficos
Autores: Perdomo-Morales, Rolando, Montero-Alejo, Vivian, Perera, Erick
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/202607
Acceso en línea:http://hdl.handle.net/10261/202607
Access Level:acceso abierto
Palabra clave:Crustacean
Clotting
Coagulation
Clotting protein
Hemolymph
Hemocytes
Transglutaminase
Invertebrates
id ES_c1aeda528d6af8de7c3391850e5d9fcd
oai_identifier_str oai:digital.csic.es:10261/202607
network_acronym_str ES
network_name_str España
repository_id_str
spelling The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the modelsPerdomo-Morales, RolandoMontero-Alejo, VivianPerera, ErickCrustaceanClottingCoagulationClotting proteinHemolymphHemocytesTransglutaminaseInvertebratesHemolymph coagulation is among the major arms of the humoral immune response in crustaceans. According to the current model, hemolymph clotting in decapod crustacean relies mostly on the polymerization of the plasmatic clotting protein (CP) which is directly promoted by calcium-depended transglutaminase (TGase) released from hemocytes upon microbial stimulus or injury. However, the type of hemocytes containing TGase, and hence how the TGase is released, might vary among species. Thus, we discourse here about possible mechanisms for clotting initiation. On the other hand, the initiation of coagulation reaction in the absence of microbial elicitors is poorly understood and seems to involve hemocytes lability, yet the mechanism remains unknown. A cellular clottable protein called coagulogen, different to the plasma CP, occurs in several species and could be related with the immune response, but the biological relevance of this protein is unknown. It is also demonstrated that the clotting response is actively involved in defense against pathogens. In addition, both TGase and the CP show pleiotropic functions, and although both proteins are relatively conserved, some of their physic-chemical properties vary significantly. The occurrence of differences in the clotting system in crustaceans is conceivable given the high number of species and their diverse ecology. Results from still non-studied decapods may provide explanation for some of the issues presented here from an evolutionary perspective.ElsevierPerera, Erick [0000-0001-6108-1340]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/202607reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.fsi.2018.09.060Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2026072026-05-22T06:33:51Z
dc.title.none.fl_str_mv The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
title The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
spellingShingle The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
Perdomo-Morales, Rolando
Crustacean
Clotting
Coagulation
Clotting protein
Hemolymph
Hemocytes
Transglutaminase
Invertebrates
title_short The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
title_full The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
title_fullStr The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
title_full_unstemmed The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
title_sort The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models
dc.creator.none.fl_str_mv Perdomo-Morales, Rolando
Montero-Alejo, Vivian
Perera, Erick
author Perdomo-Morales, Rolando
author_facet Perdomo-Morales, Rolando
Montero-Alejo, Vivian
Perera, Erick
author_role author
author2 Montero-Alejo, Vivian
Perera, Erick
author2_role author
author
dc.contributor.none.fl_str_mv Perera, Erick [0000-0001-6108-1340]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Crustacean
Clotting
Coagulation
Clotting protein
Hemolymph
Hemocytes
Transglutaminase
Invertebrates
topic Crustacean
Clotting
Coagulation
Clotting protein
Hemolymph
Hemocytes
Transglutaminase
Invertebrates
description Hemolymph coagulation is among the major arms of the humoral immune response in crustaceans. According to the current model, hemolymph clotting in decapod crustacean relies mostly on the polymerization of the plasmatic clotting protein (CP) which is directly promoted by calcium-depended transglutaminase (TGase) released from hemocytes upon microbial stimulus or injury. However, the type of hemocytes containing TGase, and hence how the TGase is released, might vary among species. Thus, we discourse here about possible mechanisms for clotting initiation. On the other hand, the initiation of coagulation reaction in the absence of microbial elicitors is poorly understood and seems to involve hemocytes lability, yet the mechanism remains unknown. A cellular clottable protein called coagulogen, different to the plasma CP, occurs in several species and could be related with the immune response, but the biological relevance of this protein is unknown. It is also demonstrated that the clotting response is actively involved in defense against pathogens. In addition, both TGase and the CP show pleiotropic functions, and although both proteins are relatively conserved, some of their physic-chemical properties vary significantly. The occurrence of differences in the clotting system in crustaceans is conceivable given the high number of species and their diverse ecology. Results from still non-studied decapods may provide explanation for some of the issues presented here from an evolutionary perspective.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/202607
url http://hdl.handle.net/10261/202607
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.fsi.2018.09.060
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418580205895680
score 15,81155

Similares en LA Referencia