Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome

10 páginas, 3 figuras, 1 tabla.-- Eunice Molinar-Toribio ... et al.

Detalles Bibliográficos
Autores: Molinar-Toribio, Eunice, Pérez-Jiménez, Jara, Jáuregui, Olga, Méndez, Lucía, Medina, Isabel, Torres, Josep Lluís
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/112613
Acceso en línea:http://hdl.handle.net/10261/112613
Access Level:acceso abierto
Palabra clave:Metabolic syndrome
n-3 PUFA
Spontaneously hypertensive obese rats
EPA/DHA
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spelling Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndromeMolinar-Toribio, EunicePérez-Jiménez, JaraJáuregui, OlgaMéndez, LucíaMedina, IsabelTorres, Josep LluísMetabolic syndromen-3 PUFASpontaneously hypertensive obese ratsEPA/DHA10 páginas, 3 figuras, 1 tabla.-- Eunice Molinar-Toribio ... et al.The increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA:DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stressThe present study work was supported by the Spanish Ministry of Science and Innovation and of Economy and Com- petitiveness (grant no. AGL2009-12374-C03-01, -02 and -03; AGL2013-49079-C2-1,2-R, respectively). The authors acknowl- edge the Panamanian Government (SENACYT/IFARHU) and the Spanish Ministry of Science and Innovation for their predoctoral fellowships to E. M.-T. and L. M., respectively. They also acknowledge ISCIII for the postdoctoral contract ‘Sara Borrell’ to J. P.-J. (CD09/00068). None of the funders had any role in the design, analysis and findings of the study or in the writing of this articlePeer reviewedCambridge University PressConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/112613reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1017/S0007114514004437Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1126132026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
title Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
spellingShingle Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
Molinar-Toribio, Eunice
Metabolic syndrome
n-3 PUFA
Spontaneously hypertensive obese rats
EPA/DHA
title_short Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
title_full Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
title_fullStr Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
title_full_unstemmed Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
title_sort Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome
dc.creator.none.fl_str_mv Molinar-Toribio, Eunice
Pérez-Jiménez, Jara
Jáuregui, Olga
Méndez, Lucía
Medina, Isabel
Torres, Josep Lluís
author Molinar-Toribio, Eunice
author_facet Molinar-Toribio, Eunice
Pérez-Jiménez, Jara
Jáuregui, Olga
Méndez, Lucía
Medina, Isabel
Torres, Josep Lluís
author_role author
author2 Pérez-Jiménez, Jara
Jáuregui, Olga
Méndez, Lucía
Medina, Isabel
Torres, Josep Lluís
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Metabolic syndrome
n-3 PUFA
Spontaneously hypertensive obese rats
EPA/DHA
topic Metabolic syndrome
n-3 PUFA
Spontaneously hypertensive obese rats
EPA/DHA
description 10 páginas, 3 figuras, 1 tabla.-- Eunice Molinar-Toribio ... et al.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/112613
url http://hdl.handle.net/10261/112613
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1017/S0007114514004437
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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