Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties
Cancer encompasses a group of pathologies with common characteristics, high incidence, and prevalence in all countries. Although there are treatments available for this disease, they are not always effective or safe, often failing to achieve the desired results. This is why it is necessary to contin...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/69526 |
| Acceso en línea: | https://hdl.handle.net/10171/69526 |
| Access Level: | acceso abierto |
| Palabra clave: | 1,4-Naphthoquinone Antitumor Cancer Cytotoxicity Drug design Quinone compound Synthesis |
| id |
ES_c0bb1deb2964f5b521926d4cb4bb502a |
|---|---|
| oai_identifier_str |
oai:dadun.unav.edu:10171/69526 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer propertiesAngulo-Elizari, E. (Eduardo)|||/items/89dc6829-c90c-46a6-84a5-6dcd6c525ee0Henriquez-Figuereo, A. (Andreina)|||/items/7738b317-9a57-4e6f-bf54-5be0d801f4feMorán-Serradilla, C. (Cristina)|||/items/ecd90d8f-35f6-4fcf-b9aa-f53d049d3185Plano-Amatriain, D. (Daniel)|||/items/238881e4-7d5e-4598-924d-4392e3b7e02eSanmartin-Grijalba, C. (Carmen)|||/items/d36bd105-ab64-427d-9745-5812cf5e7af71,4-NaphthoquinoneAntitumorCancerCytotoxicityDrug designQuinone compoundSynthesisCancer encompasses a group of pathologies with common characteristics, high incidence, and prevalence in all countries. Although there are treatments available for this disease, they are not always effective or safe, often failing to achieve the desired results. This is why it is necessary to continue the search for new therapies. One of the strategies for obtaining new antitumor drugs is the use of 1,4-naphthoquinone as a scaffold in synthetic or natural products with antitumor activity. This review focuses on compiling studies related to the antitumor activity of 1,4-naphthoquinone and its natural and synthetic derivatives over the last 10 years. The work describes the main natural naphthoquinones with antitumor activity and classifies the synthetic naphthoquinones based on the structural modifications made to the scaffold. Additionally, the formation of metal complexes using naphthoquinones as a ligand is considered. After a thorough review, 197 synthetic compounds with potent biological activity against cancer have been classified according to their chemical structures and their mechanisms of action have been described.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20242024-06-1120242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/69526reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/695262026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties |
| title |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties |
| spellingShingle |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties Angulo-Elizari, E. (Eduardo)|||/items/89dc6829-c90c-46a6-84a5-6dcd6c525ee0 1,4-Naphthoquinone Antitumor Cancer Cytotoxicity Drug design Quinone compound Synthesis |
| title_short |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties |
| title_full |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties |
| title_fullStr |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties |
| title_full_unstemmed |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties |
| title_sort |
Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties |
| dc.creator.none.fl_str_mv |
Angulo-Elizari, E. (Eduardo)|||/items/89dc6829-c90c-46a6-84a5-6dcd6c525ee0 Henriquez-Figuereo, A. (Andreina)|||/items/7738b317-9a57-4e6f-bf54-5be0d801f4fe Morán-Serradilla, C. (Cristina)|||/items/ecd90d8f-35f6-4fcf-b9aa-f53d049d3185 Plano-Amatriain, D. (Daniel)|||/items/238881e4-7d5e-4598-924d-4392e3b7e02e Sanmartin-Grijalba, C. (Carmen)|||/items/d36bd105-ab64-427d-9745-5812cf5e7af7 |
| author |
Angulo-Elizari, E. (Eduardo)|||/items/89dc6829-c90c-46a6-84a5-6dcd6c525ee0 |
| author_facet |
Angulo-Elizari, E. (Eduardo)|||/items/89dc6829-c90c-46a6-84a5-6dcd6c525ee0 Henriquez-Figuereo, A. (Andreina)|||/items/7738b317-9a57-4e6f-bf54-5be0d801f4fe Morán-Serradilla, C. (Cristina)|||/items/ecd90d8f-35f6-4fcf-b9aa-f53d049d3185 Plano-Amatriain, D. (Daniel)|||/items/238881e4-7d5e-4598-924d-4392e3b7e02e Sanmartin-Grijalba, C. (Carmen)|||/items/d36bd105-ab64-427d-9745-5812cf5e7af7 |
| author_role |
author |
| author2 |
Henriquez-Figuereo, A. (Andreina)|||/items/7738b317-9a57-4e6f-bf54-5be0d801f4fe Morán-Serradilla, C. (Cristina)|||/items/ecd90d8f-35f6-4fcf-b9aa-f53d049d3185 Plano-Amatriain, D. (Daniel)|||/items/238881e4-7d5e-4598-924d-4392e3b7e02e Sanmartin-Grijalba, C. (Carmen)|||/items/d36bd105-ab64-427d-9745-5812cf5e7af7 |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
1,4-Naphthoquinone Antitumor Cancer Cytotoxicity Drug design Quinone compound Synthesis |
| topic |
1,4-Naphthoquinone Antitumor Cancer Cytotoxicity Drug design Quinone compound Synthesis |
| description |
Cancer encompasses a group of pathologies with common characteristics, high incidence, and prevalence in all countries. Although there are treatments available for this disease, they are not always effective or safe, often failing to achieve the desired results. This is why it is necessary to continue the search for new therapies. One of the strategies for obtaining new antitumor drugs is the use of 1,4-naphthoquinone as a scaffold in synthetic or natural products with antitumor activity. This review focuses on compiling studies related to the antitumor activity of 1,4-naphthoquinone and its natural and synthetic derivatives over the last 10 years. The work describes the main natural naphthoquinones with antitumor activity and classifies the synthetic naphthoquinones based on the structural modifications made to the scaffold. Additionally, the formation of metal complexes using naphthoquinones as a ligand is considered. After a thorough review, 197 synthetic compounds with potent biological activity against cancer have been classified according to their chemical structures and their mechanisms of action have been described. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-06-11 2024 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/69526 |
| url |
https://hdl.handle.net/10171/69526 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| collection |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869418502468665344 |
| score |
15.198674 |