Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression

[EN] Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease bur- den and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced...

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Autores: Seco Calvo, Jesús Ángel, Sánchez Herráez, Sergio, Casis, Luis, Valdivia, Asier, Pérez Urzelai, Itxaro, Gil, Javier, Echevarría, Enrique
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universidad Rey Juan Carlos
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/17617
Acesso em linha:https://hdl.handle.net/10612/17617
Access Level:acceso abierto
Palavra-chave:Medicina. Salud
Synovial fluid
Peptidase activity
Knee osteoarthritis
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repository_id_str
spelling Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progressionSeco Calvo, Jesús ÁngelSánchez Herráez, SergioCasis, LuisValdivia, AsierPérez Urzelai, ItxaroGil, JavierEchevarría, EnriqueMedicina. SaludSynovial fluidPeptidase activityKnee osteoarthritis[EN] Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease bur- den and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade > 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopep- tidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP). results Synovial fluid peptidase activity varied significantly as a function of clinical signs, with dif- ferences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001) with knee effusion. Further, patients with the greatest functional impairment had signifi- cantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020), and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the renin-angiotensin system. A binary logistic regression model showed that PSA was protective (p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012). Conclusion These results suggest synovial fluid peptidase activity could play a role as a measure of dis- ease burden and predictive biomarker of progression in KOA.SIThe British Editorial Society of Bone & Joint Surgery,FisioterapiaFacultad de Ciencias de la Salud2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://hdl.handle.net/10612/17617reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad Rey Juan CarlosInglésinfo:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/176172026-06-24T12:43:27Z
dc.title.none.fl_str_mv Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
title Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
spellingShingle Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
Seco Calvo, Jesús Ángel
Medicina. Salud
Synovial fluid
Peptidase activity
Knee osteoarthritis
title_short Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
title_full Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
title_fullStr Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
title_full_unstemmed Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
title_sort Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
dc.creator.none.fl_str_mv Seco Calvo, Jesús Ángel
Sánchez Herráez, Sergio
Casis, Luis
Valdivia, Asier
Pérez Urzelai, Itxaro
Gil, Javier
Echevarría, Enrique
author Seco Calvo, Jesús Ángel
author_facet Seco Calvo, Jesús Ángel
Sánchez Herráez, Sergio
Casis, Luis
Valdivia, Asier
Pérez Urzelai, Itxaro
Gil, Javier
Echevarría, Enrique
author_role author
author2 Sánchez Herráez, Sergio
Casis, Luis
Valdivia, Asier
Pérez Urzelai, Itxaro
Gil, Javier
Echevarría, Enrique
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fisioterapia
Facultad de Ciencias de la Salud
dc.subject.none.fl_str_mv Medicina. Salud
Synovial fluid
Peptidase activity
Knee osteoarthritis
topic Medicina. Salud
Synovial fluid
Peptidase activity
Knee osteoarthritis
description [EN] Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease bur- den and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade > 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopep- tidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP). results Synovial fluid peptidase activity varied significantly as a function of clinical signs, with dif- ferences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001) with knee effusion. Further, patients with the greatest functional impairment had signifi- cantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020), and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the renin-angiotensin system. A binary logistic regression model showed that PSA was protective (p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012). Conclusion These results suggest synovial fluid peptidase activity could play a role as a measure of dis- ease burden and predictive biomarker of progression in KOA.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10612/17617
url https://hdl.handle.net/10612/17617
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The British Editorial Society of Bone & Joint Surgery,
publisher.none.fl_str_mv The British Editorial Society of Bone & Joint Surgery,
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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