Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
[EN] Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease bur- den and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad Rey Juan Carlos |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/17617 |
| Acceso en línea: | https://hdl.handle.net/10612/17617 |
| Access Level: | acceso abierto |
| Palabra clave: | Medicina. Salud Synovial fluid Peptidase activity Knee osteoarthritis |
| Sumario: | [EN] Aims To analyze the potential role of synovial fluid peptidase activity as a measure of disease bur- den and predictive biomarker of progression in knee osteoarthritis (KOA). Methods A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade > 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopep- tidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP). results Synovial fluid peptidase activity varied significantly as a function of clinical signs, with dif- ferences in levels of PEP (p = 0.020), ASP (p < 0.001), and PGAP (p = 0. 003) associated with knee locking, PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p = 0.000) with knee failure, and PEP (p = 0.006), ASP (p = 0.001), GLU (p = 0.037), and PGAP (p < 0.001) with knee effusion. Further, patients with the greatest functional impairment had signifi- cantly higher levels of APB (p = 0.005), PEP (p = 0.005), ASP (p = 0.006), GLU (p = 0.020), and PGAP (p < 0.001) activity, though not of NAP or PSA, indicating local alterations in the renin-angiotensin system. A binary logistic regression model showed that PSA was protective (p = 0.005; Exp (B) 0.949), whereas PEP (p = 0.005) and GLU were risk factors (p = 0.012). Conclusion These results suggest synovial fluid peptidase activity could play a role as a measure of dis- ease burden and predictive biomarker of progression in KOA. |
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