Conservation of aging and cancer epigenetic signatures across human and mouse
Aging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. Although many...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/259063 |
| Acceso en línea: | http://hdl.handle.net/10261/259063 |
| Access Level: | acceso abierto |
| Palabra clave: | Epigenetics Conservation DNA methylation Human Histone modification Mouse |
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Conservation of aging and cancer epigenetic signatures across human and mouse |
| title |
Conservation of aging and cancer epigenetic signatures across human and mouse |
| spellingShingle |
Conservation of aging and cancer epigenetic signatures across human and mouse Pérez, Raúl F. Epigenetics Conservation DNA methylation Human Histone modification Mouse |
| title_short |
Conservation of aging and cancer epigenetic signatures across human and mouse |
| title_full |
Conservation of aging and cancer epigenetic signatures across human and mouse |
| title_fullStr |
Conservation of aging and cancer epigenetic signatures across human and mouse |
| title_full_unstemmed |
Conservation of aging and cancer epigenetic signatures across human and mouse |
| title_sort |
Conservation of aging and cancer epigenetic signatures across human and mouse |
| dc.creator.none.fl_str_mv |
Pérez, Raúl F. Tejedor, Juan Ramón Santamarina-Ojeda, Pablo López, Virginia Urdinguio, Rocío G. Villamañán, Lucía Candiota, Ana Paula Vidal Sarró, Noemí Barradas, Marta Fernández-Marcos, Pablo José Serrano, Manuel Fernández, Agustín F. Fraga, Mario F. |
| author |
Pérez, Raúl F. |
| author_facet |
Pérez, Raúl F. Tejedor, Juan Ramón Santamarina-Ojeda, Pablo López, Virginia Urdinguio, Rocío G. Villamañán, Lucía Candiota, Ana Paula Vidal Sarró, Noemí Barradas, Marta Fernández-Marcos, Pablo José Serrano, Manuel Fernández, Agustín F. Fraga, Mario F. |
| author_role |
author |
| author2 |
Tejedor, Juan Ramón Santamarina-Ojeda, Pablo López, Virginia Urdinguio, Rocío G. Villamañán, Lucía Candiota, Ana Paula Vidal Sarró, Noemí Barradas, Marta Fernández-Marcos, Pablo José Serrano, Manuel Fernández, Agustín F. Fraga, Mario F. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Asociación Española Contra el Cáncer Fundación General CSIC European Commission Instituto de Salud Carlos III Principado de Asturias European Commission Fundación Ramón Areces Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Universidad Autónoma de Barcelona Ministerio de Economía y Competitividad (España) Obra Social Cajastur Liberbank Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Epigenetics Conservation DNA methylation Human Histone modification Mouse |
| topic |
Epigenetics Conservation DNA methylation Human Histone modification Mouse |
| description |
Aging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. Although many of these observations arise from the use of mouse models, there is a lack of systematic comparisons of human and mouse epigenetic patterns in the context of disease. However, such comparisons are significant as they allow to establish the extent to which some of the observed similarities or differences arise from pre-existing species-specific epigenetic traits. Here, we have used reduced representation bisulfite sequencing to profile the brain methylomes of young and old, tumoral and nontumoral brain samples from human and mouse. We first characterized the baseline epigenomic patterns of the species and subsequently focused on the DNA methylation alterations associated with cancer and aging. Next, we described the functional genomic and epigenomic context associated with the alterations, and finally, we integrated our data to study interspecies DNA methylation levels at orthologous CpG sites. Globally, we found considerable differences between the characteristics of DNA methylation alterations in cancer and aging in both species. Moreover, we describe robust evidence for the conservation of the specific cancer and aging epigenomic signatures in human and mouse. Our observations point toward the preservation of the functional consequences of these alterations at multiple levels of genomic regulation. Finally, our analyses reveal a role for the genomic context in explaining disease- and species-specific epigenetic traits. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/259063 |
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http://hdl.handle.net/10261/259063 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Oxford University Press |
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Oxford University Press |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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Conservation of aging and cancer epigenetic signatures across human and mousePérez, Raúl F.Tejedor, Juan RamónSantamarina-Ojeda, PabloLópez, VirginiaUrdinguio, Rocío G.Villamañán, LucíaCandiota, Ana PaulaVidal Sarró, NoemíBarradas, MartaFernández-Marcos, Pablo JoséSerrano, ManuelFernández, Agustín F.Fraga, Mario F.EpigeneticsConservationDNA methylationHumanHistone modificationMouseAging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. Although many of these observations arise from the use of mouse models, there is a lack of systematic comparisons of human and mouse epigenetic patterns in the context of disease. However, such comparisons are significant as they allow to establish the extent to which some of the observed similarities or differences arise from pre-existing species-specific epigenetic traits. Here, we have used reduced representation bisulfite sequencing to profile the brain methylomes of young and old, tumoral and nontumoral brain samples from human and mouse. We first characterized the baseline epigenomic patterns of the species and subsequently focused on the DNA methylation alterations associated with cancer and aging. Next, we described the functional genomic and epigenomic context associated with the alterations, and finally, we integrated our data to study interspecies DNA methylation levels at orthologous CpG sites. Globally, we found considerable differences between the characteristics of DNA methylation alterations in cancer and aging in both species. Moreover, we describe robust evidence for the conservation of the specific cancer and aging epigenomic signatures in human and mouse. Our observations point toward the preservation of the functional consequences of these alterations at multiple levels of genomic regulation. Finally, our analyses reveal a role for the genomic context in explaining disease- and species-specific epigenetic traits.This work was supported by the Spanish Association Against Cancer (PROYE18061FERN to M.F.F.), the Asturias Government (PCTI) cofunding 2018-2022/FEDER (IDI/2018/146 to M.F.F.), Fundación General CSIC (0348_CIE_6_E to M.F.F.), and the Health Institute Carlos III (Plan Nacional de I + D+I) cofunding FEDER (PI15/00892 and PI18/01527 to M.F.F and A.F.F.). They also acknowledge support from the Ramón Areces Foundation (CIVP18A3891 to P.J.F.M.), the AECC (SIRTBIO to P.J.F.M.), the MICINN (SAF2017-85766-R to P.J.F.M.), a Ramón y Cajal fellowship (MICINN, RYC-2017-22335 to P.J.F.M.), and the European Commission ATTRACT project (777222 to A.P.C.). J.R.T. is supported by a Juan de la Cierva fellowship from the Spanish Ministry of Science and Innovation (FJCI-2015-26965). R.F.P. and P.S.O. are supported by the Severo Ochoa program (BP17-114 and BP17-165, respectively). R.G.U. is supported by the Centro de Investigación Biomédica en Red de Enfermedades Raras (Health Institute Carlos III). L.V. was supported by the UAB Predoctoral training programme (PIF predoctoral fellowships). They also acknowledge support from the IMDEA Food Institute and IUOPA-ISPA-FINBA (the IUOPA is supported by the Obra Social Cajastur-Liberbank, Spain).Peer reviewedOxford University PressAsociación Española Contra el CáncerFundación General CSICEuropean CommissionInstituto de Salud Carlos IIIPrincipado de AsturiasEuropean CommissionFundación Ramón ArecesAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Universidad Autónoma de BarcelonaMinisterio de Economía y Competitividad (España)Obra Social CajasturLiberbankInstituto Madrileño de Investigación y Desarrollo Rural, Agrario y AlimentarioConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/259063reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-85766-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC-2017-22335info:eu-repo/grantAgreement/EC/H2020/777222info:eu-repo/grantAgreement/MINECO//FJCI-2015-26965https://doi.org/10.1093/molbev/msab112Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2590632026-05-22T06:33:51Z |
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