Epigenetic and Epitranscriptomic Control in Prostate Cancer
The initiation of prostate cancer has been long associated with DNA copy-number alter-ations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emer...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/282839 |
| Acceso en línea: | http://hdl.handle.net/10261/282839 |
| Access Level: | acceso abierto |
| Palabra clave: | Epigenetics DNA methylation Histone modifications Epitranscriptomics RNA modifications Prostate cancer Novel therapeutics |
| Sumario: | The initiation of prostate cancer has been long associated with DNA copy-number alter-ations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer. |
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