Interim Results from the IMPACT Study

Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. To report the utility of PSA screening, PrCa incidence, positive predictive va...

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Autores: Page, Elizabeth C., Bancroft, Elizabeth|||0000-0002-5482-5660, Brook, Mark N.|||0000-0002-8969-2378, Assel, Melissa, Hassan Al Battat, Mona, Thomas, Sarah, Taylor, Natalie, Chamberlain, Anthony, Pope, Jennifer, Raghallaigh, Holly Ni, Evans, Gareth|||0000-0002-8482-5784, Rothwell, Jeanette, Maehle, Lovise, Grindedal, Eli Marie, James, Paul|||0000-0002-4361-4657, Mascarenhas, Lyon, McKinley, Joanne, Side, Lucy, Thomas, Tessy, van Asperen, Christi, Vasen, Hans|||0000-0003-2682-2603, Kiemeney, Lambertus A., Ringelberg, Janneke, Jensen, Thomas Dyrso, Osther, Palle Jörn Sloth|||0000-0001-7962-1640, Helfand, Brian T., Genova, Elena, Oldenburg, Rogier A., Cybulski, Cezary|||0000-0002-2819-3057, Wokolorczyk, Dominika, Ong, Kai-Ren, Huber, Camilla, Lam, Jimmy, Taylor, Louise, Salinas, Monica, Feliubadaló, Lidia|||0000-0002-1736-0112, Oosterwijk, Jan C., van Zelst-Stams, Wendy, Cook, Jackie, Rosario, Derek J.|||0000-0002-9086-3592, Domchek, Susan M.|||0000-0002-5914-7272, Powers, Jacquelyn, Buys, Saundra|||0000-0003-4120-5697, O'Toole, Karen, Ausems, Margreet G. E. M., Schmutzler, Rita K., Rhiem, Kerstin, Izatt, Louise|||0000-0003-1258-4843, Tripathi, Vishakha, Teixeira, Manuel R.|||0000-0002-4896-5982, Cardoso, Marta|||0000-0002-3633-1659, Foulkes, William|||0000-0001-7427-4651, Aprikian, Armen, van Randeraad, Heleen, Davidson, Rosemarie, Longmuir, Mark, Ruijs, Marielle W.G., Helderman van den Enden, Apollonia T.J.M., Adank, Muriel A., Williams, Rachel|||0000-0001-6353-944X, Andrews, Lesley, Murphy, Declan G., Halliday, Dorothy, Walker, Lisa, Liljegren, Annelie, Carlsson, Stefan, Azzabi, Ashraf, Jobson, Irene, Morton, Catherine, Shackleton, Kylie, Snape, Katie, Hanson, Helen, Harris, Marion, Tischkowitz, Marc, Taylor, Amy, Kirk, Judy, Susman, Rachel, Chen-Shtoyerman, Rakefet|||0000-0002-5055-5907, Spigelman, Allan, Pachter, Nicholas, Ahmed, Munaza, Ramon y Cajal, Teresa|||0000-0003-3490-3585, Zgajnar, Janez, Brewer, Carole, Gadea, Neus|||0000-0002-6736-3979, Brady, Angela F., Van Os, Theo, Gallagher, David, Johannsson, Oskar, Donaldson, Alan|||0000-0001-9193-4172, Barwell, Julian, Nicolai, Nicola|||0000-0002-5718-2699, Friedman, Eitan|||0000-0002-6745-1733, Obeid, Elias|||0000-0001-5120-9435, Greenhalgh, Lynn, Murthy, Vedang|||0000-0001-6011-9319, Copakova, Lucia, Saya, Sibel|||0000-0002-4796-6852, McGrath, John, Cooke, Peter, Rønlund, Karina, Richardson, Kate, Henderson, Alex, Teo, Soo|||0000-0002-0444-590X, Arun, Banu K., Kast, Karin|||0000-0001-6531-755X, Dias, Alexander, Aaronson, Neil K., Ardern-Jones, Audrey, Bangma, Chris H., Castro, Elena|||0000-0002-3691-6454, Dearnaley, David|||0000-0002-3954-2806, Eccles, Diana M.|||0000-0002-9935-3169, Tricker, Karen, Eyfjord, Jorunn, Falconer, Alison, Foster, Christopher, Gronberg, Henrik, Hamdy, Freddie C.|||0000-0003-2627-2154, Stefansdottir, Vigdis|||0000-0003-4451-3126, Khoo, Vincent, Lindeman, Geoffrey J.|||0000-0001-9386-2416, Lubinski, Jan|||0000-0003-2931-3003, Axcrona, Karol|||0000-0002-5011-0107, Mikropoulos, Christos|||0000-0001-8070-2851, Mitra, Anita, Moynihan, Clare, Rennert, Gad|||0000-0002-8512-068X, Suri, Mohnish|||0000-0001-9037-701X, Wilson, Penny, Dudderidge, Tim|||0000-0001-6373-3613, Offman, Judith|||0000-0001-5604-1635, Kote-Jarai, Zsofia|||0000-0002-6329-5155, Vickers, Andrew J.|||0000-0003-1525-6503, Lilja, Hans|||0000-0001-5871-7846, Eeles, Rosalind|||0000-0002-3698-6241
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:286297
Acceso en línea:https://ddd.uab.cat/record/286297
https://dx.doi.org/urn:doi:10.1016/j.eururo.2019.08.019
Access Level:acceso abierto
Palabra clave:BRCA1
BRCA2
Prostate-specific-antigen
Prostate cancer
Targeted prostate screening
Descripción
Sumario:Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. To report the utility of PSA screening, PrCa incidence, positive predictive value of PSA, biopsy, and tumour characteristics after 3 yr of screening, by BRCA status. Men aged 40-69 yr with a germline pathogenic BRCA1/2 mutation and male controls testing negative for a familial BRCA1/2 mutation were recruited. Participants underwent PSA screening for 3 yr, and if PSA.