Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers

Background Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA...

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Autores: Bancroft, Elizabeth|||0000-0002-5482-5660, Page, Elizabeth C., Castro, Elena|||0000-0002-3691-6454, Lilja, Hans|||0000-0001-5871-7846, Vickers, Andrew J.|||0000-0003-1525-6503, Sjoberg, Daniel, Assel, Melissa, Foster, Christopher, Mitchell, Gillian, Drew, Kate, Maehle, Lovise Olaug, Axcrona, Karol|||0000-0002-5011-0107, Evans, Gareth|||0000-0002-8482-5784, Bulman, Barbara, Eccles, Diana M.|||0000-0002-9935-3169, McBride, Donna, Van Asperen, Christi J., Vasen, Hans|||0000-0003-2682-2603, Kiemeney, Lambertus A.L.M.|||0000-0002-2368-1326, Ringelberg, Janneke, Cybulski, Cezary|||0000-0002-2819-3057, Wokolorczyk, Dominika, Selkirk, Christina, Hulick, Peter J., Bojesen, Anders|||0000-0003-4289-8595, Skytte, Anne-Bine|||0000-0002-0067-9557, Lam, Jimmy, Taylor, Louise, Oldenburg, Rogier A., Cremers, Ruben, Verhaegh, Gerald|||0000-0003-0227-2280, Van Zelst-Stams, Wendy A., Oosterwijk, Jan C., Blanco Guillermo, Ignacio|||0000-0002-7414-7481, Salinas, Monica, Cook, Jacqueline A., Rosario, Derek J.|||0000-0002-9086-3592, Buys, Sandra S., Conner, Thomas A., Ausems, Margreet|||0000-0003-0305-3477, Ong, Kairen, Hoffman, Jonathan, Domchek, Susan M.|||0000-0002-5914-7272, Powers, Jacquelyn M., Teixeira, Manuel R.|||0000-0002-4896-5982, Maia, Sofia F., Foulkes, William|||0000-0001-7427-4651, Taherian, Nassim, Ruijs, Marielle, Den Enden, Apollonia T. Helderman-van, Izatt, Louise|||0000-0003-1258-4843, Davidson, Rosemarie H., Adank, Muriel A., Walker, Lisa J., Schmutzler, Rita, Tucker, Kathy M., Kirk, Judy, Hodgson, Shirley Victoria, Harris, Marion T., Douglas, Fiona S., Lindeman, Geoffrey J.|||0000-0001-9386-2416, Zgajnar, Janez, Tischkowitz, Marc D., Clowes, Virginia E., Susman, Rachel, Ramon y Cajal, Teresa|||0000-0003-3490-3585, Patcher, Nicholas, Gadea, Neus|||0000-0002-6736-3979, Spigelman, Allan, Van Os, Theo, Liljegren, Annelie, Side, Lucy E., Brewer, Carole M., Brady, Angela F., Donaldson, Alan|||0000-0001-9193-4172, Stefansdottir, Vigdis|||0000-0003-4451-3126, Friedman, Eitan A., Chen-Shtoyerman, Rakefet|||0000-0002-5055-5907, Amor, David|||0000-0001-7191-8511, Copakova, Lucia, Barwell, Julian G., Giri, Veda|||0000-0002-7268-5913, Murthy, Vedang|||0000-0001-6011-9319, Nicolai, Nicola|||0000-0002-5718-2699, Teo, Soo|||0000-0002-0444-590X, Greenhalgh, Lynn, Strom, Sara S., Henderson, Alex, McGrath, John, Gallagher, David James, Aaronson, Neil K., Ardern-Jones, Audrey T., Bangma, Chris H., Dearnaley, David P., Costello, Philandra, Eyfjord, Jórunn Erla, Rothwell, Jeanette, Falconer, Alison, Gronberg, Henrik, Hamdy, Freddie C.|||0000-0003-2627-2154, Johannsson, Óskar Th, Khoo, Vincent S., Kote-Jarai, Zsofia S., Lubinski, Jan|||0000-0003-2931-3003, Axcrona, Ulrika, Melia, Jane Westfield, McKinley, Joanne M., Mitra, Anita Vanessa, Moynihan, Clare, Rennert, Gad|||0000-0002-8512-068X, Suri, Mohnish|||0000-0001-9037-701X, Wilson, Penny, Killick, Emma, Moss, Susan Mary, Eeles, Rosalind|||0000-0002-3698-6241
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:301837
Acceso en línea:https://ddd.uab.cat/record/301837
https://dx.doi.org/urn:doi:10.1016/j.eururo.2014.01.003
Access Level:acceso abierto
Palabra clave:BRCA1
BRCA2
Prostate cancer
Prostate-specific antigen
Targeted screening
Descripción
Sumario:Background Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations. Objective To report the first year's screening results for all men at enrolment in the study. Design, setting and participants We recruited men aged 40-69 yr with germline BRCA1/2 mutations and a control group of men who have tested negative for a pathogenic BRCA1 or BRCA2 mutation known to be present in their families. All men underwent prostate-specific antigen (PSA) testing at enrolment, and those men with PSA.

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