Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis

Objective: To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex. Design: Cross-sectional, observational study. Methods: The study was conducted in 297 eyes of 297 healthy...

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Detalles Bibliográficos
Autores: Nieves Moreno, María, Martínez De La Casa Fernández-Borrella, José María, Morales Fernández, Laura, Sánchez Jean, Rubén, Sáenz Francés, Federico, García Feijoo, Julián
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12017
Acceso en línea:https://hdl.handle.net/20.500.14352/12017
Access Level:acceso abierto
Palabra clave:617.735-073.75
611.843-053
Eyes
Tomography
Retina
Nerve fibers
Epithelium
Photoreceptors
Ganglion cells
OCT
Diagnóstico por imagen y medicina nuclear
Oftalmología
3204.01 Medicina Nuclear
3201.09 Oftalmología
Descripción
Sumario:Objective: To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex. Design: Cross-sectional, observational study. Methods: The study was conducted in 297 eyes of 297 healthy subjects aged 18 to 87 years. In one randomly selected eye of each participant the volume and mean thicknesses of the different macular layers were measured by SD-OCT using the instrument's macular segmentation software. Main outcome measures: Volume and mean thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigmentary epithelium (RPE) and photoreceptor layer (PR). Results: Retinal thickness was reduced by 0.24 μm for every one year of age. Age adjusted linear regression analysis revealed mean GCL, IPL, ONL and PR thickness reductions and a mean OPL thickness increase with age. Women had significantly lower mean GCL, IPL, INL, ONL and PR thicknesses and volumes and a significantly greater mRNFL volume than men. Conclusion: The thickness of most retinal layers varies both with age and according to sex. Longitudinal studies are needed to determine the rate of layer thinning produced with age.

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